Browsing by Author "Fekade, Seife"

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    Clinical Characteristics and Predictors of Outcome of Lupus nephritis Patients on Follow up at Two Centers in Addis Ababa, Ethiopia from August 1, 2016 up to August 30, 2020
    (Addis Abeba University, 2020-12) Fekade, Seife; Tadesse, Yewondwossen (MD, Internist, Consultant Nephrologist)
    Background: SLE is a multisystem chronic autoimmune disease which commonly involves the kidney and is associated with high mortality and morbidity especially in populations of African descent. Objective: To describe the clinical characteristics, treatment patterns and predictors of outcome in a group of Ethiopia lupus nephritis patients from two centers. Patients and Methods: The records of 97 lupus nephritis patients on follow up from August 1, 2016 up to August 30, 2020 in two centers, Tikur Anbessa specialized hospital and a private practice center (Shebelle Higher Clinic), Addis Ababa, Ethiopia were reviewed to acquire data on clinical characteristics and outcome. All patients fulfilled 2012 SLICC criteria for SLE. Result: There were a total of 89 females and 8 male patients. Mean age at presentation of LN was 27.4 with 80(82.5%) of patients having LN as first presentation of SLE. Nephrotic range proteinuria was present in 27% and impaired kidney function was seen in 51.6% at presentation. Kidney biopsy done for 17 patients showed Class III and class IV as the commonest types. 70(74.5%) patients received immunosuppressive therapy with cyclophosphamide and MMF used in the majority. Favorable outcome was seen in 73(73.7%) after 6 months of therapy. After a median follow up of 41 months, 71.3% of patients had favorable outcome, 8(8.5%) patients had died and 1(1.1%) developed ESRD. Follow up at Tikur Anbessa specialized hospital, renal flare history and absence of response at 6 months were found to be significantly associated with unfavorable outcome. Conclusion: LN, in this study of Ethiopian patients, is mostly diagnosed concomitantly with SLE and it presents at a younger age group and with more degrees of kidney impairment, but has response to treatment comparable to most other series.