Browsing by Author "Fantaw, Debalke"

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    Assessment of the Survival Status and Risk Factors for the Mortality of Multidrug Resistant Tuberculosis Patients at Adama and Bishoftu General Hospitals, Oromia, Ethiopia.
    (Addis Ababa Universty, 2018-07) Fantaw, Debalke; Nedi, Teshome (PhD)
    Assessment of Survival Status and Risk Factors for Mortality of Multidrug Resistant Tuberculosis Patients at Adama and Bishoftu General Hospitals, Oromia, Ethiopia. Debalke Fantaw, Addis Ababa University, 2018 Multi-drug resistant tuberculosis is a wide spreading global problem. The magnitude of this disease varies significantly from country to country and the treatment outcomes are inadequately described in Ethiopia. Hence, this study aims to assess the survival status and risk factors for mortality of multidrug resistant tuberculosis patients at Adama and Bishoftu General Hospitals. Retrospective cross-sectional study design was conducted among cohorts of multidrug resistant tuberculosis patients treated from May 2013 to August 2017 at Adama and Bishoftu General Hospitals. Data were collected using data abstraction format from 164 patient cards. All patients were used as study participants. Data were analyzed using STATA Version 13 statistical software. Risks were estimated for the entire follow-up time corresponding to each event occurrence using Kaplan-Meier method and the covariates were fitted to Cox Proportional Hazard Regression Model where 164 patients were followed for a total of 63,141 person-days. The median survival time was 400.5 days or 1.1 year. Among 164 patients, 74 (45.10%) were male and the mean age was 31.5 years. There were 30 (18.30%) known deaths and the survival probability of the study participants at 6, 12, 18 and 24 months of treatment was 84%, 82%, 81% and 72%, respectively. In this study: HIV, co-morbidities and co-infections, low initial body weight, age, occupation and Khat use were identified as risk factors for the death of MDR-TB patients. Comparison of these risk factors showed that there is a significant difference in the probability of survival on MDR-TB patients. Cox Regression analysis Model result showed that factors independently associated with mortality of patients were: HIV (HR=2.75,95%CI(1.23-6.15) &P=0.01); low initial body weight(HR=0.44,95% CI(0.22-0.85) &P=0.02); co-morbidities & co-infections (HR=2.28,95% CI (1.99- 5.26) & P=0.05); age (HR=2.3,95% CI(1.35-3.79) & P=0.00); Khat use (HR=0.41, 95% CI (0.18-0.97) & P=0.04); Occupation (HR=1.31,95% CI (1.06-1.63) & P=0.01). In conclusion, a higher death rate was noted in patients who started MDR-TB treatment with initial low body weight, HIV positive, co-morbidities & co-infections, age and Khat user.