Browsing by Author "Dessalegn, Mekonnen"

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    Assessment of Chemotherapy induced Leukopenia and its determinants among solid cancer patients attending St. Paul Hospital Millennium Medical College Oncology Unit, Addis Ababa, Ethiopia
    (Addis Abeba University, 2020-05) Dessalegn, Mekonnen; Tsegaye, Aster(PhD, Associate Professor); Fantahun, Mengistu (MSc); Adem, Abdum (MD, Assistant professor of Clinical Oncology); Hussein, Mintewab(MSc)
    Background: Chemotherapy is among the standard treatments for cancer and leukopenia, neutropenia, febrile neutropenia and lymphopenia are the most common side effects. These side effects have been reported to be associated with substantial morbidity, mortality and healthcare costs. Objectives: To assess the prevalence of chemotherapy induced leukopenia (CIL) in solid cancer patients at St Paul‟s Hospital Millennium Medical College Oncology unit, Addis Ababa, Ethiopia. Methods: An institution based cross sectional study was performed at St Paul‟s Hospital Millennium Medical College Oncology unit from February 1st 2020 to May 2020. Using convenient sampling technique, 92 patients, who were diagnosed for any type of solid cancer, were recruited in this study. EDTA whole blood was collected before each cycle of treatments and analyzed for complete blood count (CBC) using Beckman coulter analyzer before and after the initiation of chemotherapy. The laboratory analysis was done for five times Data were entered; cleared and analyzed to match the objectives. Chi-square statistics were employed and p values less than 0.05 were taken as statistically significant. Results: Among the 92 patients who participated in this study, the following adverse effects were observed after the use of various chemotherapy regiments in the five cycles. The most common adverse effects of Chemotherapy Are Leukopenia 80.4%, Neutropenia 70.7 %, Febrile Neutropenia 50% and Lymphopenia 88%. occupation and ECOG have a significant association with the occurrence of hematological toxicities with (p=0.011) and (P=0.013) respectively. Also majority of hematological toxicities are caused by Adriamycin + cyclophosphamide. Conclusion: Even though chemotherapy is the standard treatment for cancer patients, it causes leukopenia, neutropenia, febrile neutropenia and lymphopenia which may cause delaying of treatment, morbidity and mortality.