Browsing by Author "Desalegn Fekadu"

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    Determinants of Surgical Management Outcome for Esophageal Cancer Patients Treated at Tikur anbessa Speclized Hospital Minilik ll Hoospital st Peter Hospital Addis Ababa Ethiopia Multi-Centre Study
    (Addis Ababa University, 2024-07-10) Desalegn Fekadu; Berhanu Nega
    Introduction: Esophageal cancer (EC) is an insidious malignant disease affecting the esophagus, originates in the esophagus, muscular tube between the throat and stomach. It has two major histological subtypes: squamous cell carcinoma and adenocarcinoma. Globally, esophageal cancer is the seventh leading type of cancer and in addition, it remains a significant cause of mortality and morbidity worldwide. The management of esophageal cancer involves a multidisciplinary approach, including surgery, radiation therapy, and chemotherapy. The study aims to shed light on the various elements affecting the success of esophageal cancer surgical management, ranging from patient demographics to treatment modalities employed at TASH, Minilik II and St Peter Hospitals. Objectives: Determinants of surgical management outcome for esophageal cancer among patients treated at Tikur Anbessa specialized hospital Minilik II Hospital and St Peter Hospital, Addis Ababa, Ethiopia, 2021-2024. Methods: A retrospective cohort study was conducted among patients treated at Tikur Anbessa specialized hospital, Minilik II Hospital and St Peter Hospital. The study subjects were all esophageal cancer patients treated at TASH, Minilik II Hospital and St Peter Hospital over the last three years. Data were collected using a semi-structured questionnaire and checklist. Data were entered and analyzed using SPSS version 20 and EPI-info version 7 statistical packages. In the analysis process, frequency distribution of variables was calculated. To ascertain the association between dependent and independent variables, odds ratio with 95% confidence interval was calculated. A multiple logistic regression used to estimate the magnitude impact of each predictor variables on outcome variable after adjusting for all other predictors in the model. Results: The finding of this study revealed the overall good esophageal surgical treatment outcomes treated at TASH, Minilik II Hospital and St Peter Hospital in Addis Ababa, Ethiopia found to be 110(91.2%). Accordingly, the findings highlight the complex interplay of various factors influencing surgical outcomes in esophageal cancer. Older age, advanced disease stage, the presence of co-existing health conditions, blood loss during surgery, and Post-Operative Complications were factors positive predictors’ of increased mortality after esophageal cancer surgery. Conclusion and recommendations: There was a high mortality rate. Age, comorbidity, blood loss in surgery and post-operative complication are mortality predictors’ in esophageal surgery. Hence, it is essential to improve the survival of patients through early detection and timely initiation of the available treatment options. Key Words: Esophageal, surgical outcomes, TASH.