Browsing by Author "Assefa Mekuriaw"

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    Bioassay Guided Phytochemical Investigation on Roots of Taverniera Abyssinica (Dingetegna)
    (Addis Ababa Universty, 2010-07) Assefa Mekuriaw; Dagne Ermias (Professor)
    The chemical constituents in EtOAc extract of the Ethiopian traditional medicinal plant ‘Dingetegna”, Taverniera abyssinica, were reinvestigated and the claimed antispasmodic activity of them were examined. The chemical constituents were isolated and purified by various chromatographic methods and their structures were elucidated mainly by NMR. The two compounds isolated were identified as 3-hydroxy-9-methoxypterocarpan, a known compound called medicarpin and 3,4-dihydroxypterocarpan (4-hydroxymedicarpin). Both compounds antagonized the histamine induced contraction of guinea pig ileum. Medicarpin was more active than its natural derivative 4-hydroxymedicarpin.