Browsing by Author "Assefa, Etsegenet"

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    Assessment of Malnutrition and Inflammatory status in cervical cancer patients attending Tikur Anbessa specialized hospital.
    (Addis Abeba University, 2021-06) Assefa, Etsegenet; Dr.Degef, Maria; Dr.Tigeneh, Wondemagegnhu; Dr. Gnanasekaran, Ñatesan
    Background: Globally cervical Cancer is the fourth common cancer accounting for 6.6% of all female cancers. Oncogenic human papillomavirus (HPV) specifically types 16 and 18 is the most important risk factor associated with cervical cancer. Studies have indicated that approximately 88.33% of gynecological cancer patients experience malnutrition; and Inflammation that play a pivotal role in the progression of cervical cancer. Various nutritional and inflammatory parameters such as serum Total Protein, Albumin, Ferritin and Hematological parameters; Hemoglobin, LMR NLR, RDW and PLR used as Prognostic Biomarker of cancer associated with inflammation and malnutrition in cervical cancer patient. Objective: The aim of the present study was Assessment of Malnutrition and Inflammatory Status in Cervical Cancer Patients attending Tikur Anbessa Specialized Hospital. Methodology: Hospital based comparative cross-sectional study was conducted on 50 cervical cancer patients and 50 healthy individuals. Socio demographic data were collected by using standardized questionnaire. Anthropometric data and Blood collection was done through standardized techniques and Automated COBAS 6000 and Sysmex KX-21N hematology analyzers were used to analyze the samples. Statistical data analysis was held by SPSS version 25. Student’s t-test was used to compare the mean value of continuous variables of two groups, one way analysis of variance (ANOVA) was used to compare the relationship of categorical variables between deferent stages of the cancer. Other associations were performed with Pearson’s correlation coefficient. A P-value of <0.05 at 95% confidence level was considered to be statistically significant in all the analyses. Result: The mean age of cervical cancer patient and control group was 52.4 years. The cervical cancer Patients had significantly decreased Albumin and increased Total Protein and significantly increased Ferritin levels than controls group. Among hematological parameters there was a significantly increases in Red blood distribution width (RDW), Neutrophiles to Lymphocytes ratio (NLR) and Platelet to Lymphocytes ratio (PLR). There was also decrease in Hemoglobin and Lymphocyte to Monocyte ratio (LMR) in the cervical cancer Patients and also those parameters expresses their effect in cervical cancer from stage II to stage IV. Albumin negatively correlated with serum ferritin (r=-0.120*, p=0.002) and RDW (r=-0.018*, p= 0.001) in cervical cancer patient and negatively correlated with serum total protein (r=0.943*, P<0.001) in control group. NLR positively correlated with PLR (r=0.764**, p=0.000) and LMR (R=1.000**, P=0.000) in cervical cancer patients. Conclusions: Malnutrition and inflammation are common experience in patients with cervical cancer. The result of this study showed low level of serum Albumin, Hemoglobin and LMR; and high level of serum Total Protein, Ferritin and other Hematological Parameters such as NLR, RDW and PLR. This may serve as markers for assessment of malnutrition and inflammation and may also use as a prognostic factor in cervical cancer patients. Therefore, further study is recommended on the assessment of malnutrition and inflammation in cervical cancer patients with a large group of participants.