Browsing by Author "Aseme,Afewerk Habtamu"

Now showing 1 - 1 of 1
  • No Thumbnail Available
    Item
    Assessment of Serum Amylase and Lipase Levels and associated factors among Type 2 Diabetes Mellitus follow up Patients at Hakim Gizaw Teaching Hospital Debre Berhan, Ethiopia
    (Addis Ababa University, 2025-07) Aseme,Afewerk Habtamu; Kinde,Samuel(MSc, PhD fellow); Dedefo,Gobena(MSc)
    Background: Diabetes mellitus is the leading non communicable disease in most low and middle income countries. Due to lack of proper follow up tools in most peripheral areas, majority of patients attending follow-up appointment at diabetic clinics failed to maintain good glycemic control causing destruction of the exocrinal cells of pancreas resulting in impaired secretion of pancreatic amylase and lipase. Therefore, assessment of serum amylase and lipase in uncontrolled and controlled type 2 diabetes may possibly help to effectively manage diabetes mellitus. Objective: To assess the level of serum amylase and lipase and associated factors among type 2 diabetic follow-up patients, 2025. Methods: A hospital based comparative cross-sectional study design from February 05 to March 30, 2025 was conducted at Hakim Gizaw Teaching Hospital Debre Berhan, Ethiopia with a total of 112(56 controlled and 56 uncontrolled) type 2 diabetes mellitus (T2DM) patients recruited using convenient sampling technique. Sociodemographic data was collected by face to face interview using pre tested questionnaire. HbA1c, FBS, Serum amylase, and Serum lipase was measured using Siemens Dimension EXL 200 clinical chemistry analyzer. IBM SPSS Version 27 was utilized for data entry, clearing and analysis with a significance level of P <0.05. Result: The mean level of serum amylase and lipase were significantly decreased in uncontrolled T2DM than controlled T2DM (p<0.001). Serum amylase level showed statistically significant negative correlation with duration of DM (r = -0.599, p <0.001), Waist to Hip ratio (WHR) (r = 0.249, p = 0.008), SBP (r = -0.251, p = 0.008), DBP (r = -0.257, p = 0.006), FBS (r = -0.478, p = <0.001) and HbA1c (r = -0.575, p = <0.001). Serum lipase had a strong negative correlation with duration of DM (r = -0.484, p <0.001), FBS (r = -0.625, p = <0.001) and HbA1c (r = -0.679, p = <0.001). Increased HbA1c, taking OHA, abdominal discomfort were key associated factors for decreased serum amylase and lipase. The AUC from ROC curve for serum amylase and lipase was 0.849 and 0.955 respectively indicating the effectiveness of these enzymes to investigate glycemic status in T2DM. Conclusion: The study demonstrated that uncontrolled T2DM patients have significantly decreased serum amylase and lipase this might be due to destruction of exocrine compartment of pancreas. Therefore, these enzymes might be additional biomarkers to manage T2DM and further large scale studies are recommended to investigate their diagnostic role to predict glycemic control among T2DM.