Browsing by Author "Asaminew Goa"

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    Synthesis, In vitro Antimicrobial and in silico Studies of Aminoalkyl Derivatives of Carvacrol
    (Addis Ababa University, 2025-05-13) Asaminew Goa; Daniel Bisrat
    The global rise of antimicrobial resistance has created an urgent need for the development of new antimicrobial agents. Carvacrol, a natural phenolic compound, has drawn significant attention in medicinal chemistry due to its broad-spectrum biological activities. In the present study, two novel aminoalkyl derivatives of carvacrol were successfully synthesized through a Mannich-type reaction, which involves the condensation of carvacrol with formaldehyde and a secondary amine (dimethylamine or piperdine). Structural confirmation of the synthesized derivatives was carried out using spectroscopic techniques (1H-NMR and 13C-NMR). Based on the spectral data, the compounds were identified as 4-((dimethylamino)methyl)-5-isopropyl-2-