Browsing by Author "Alemu Desalegn"

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    Assessement of Platelet Parameters among Adult Ptb Patients at Two Hcs, in Nsc and Lsc, Addis Ababa, Ethiopia.
    (Addis Ababa University, 2024-07-30) Alemu Desalegn; JEMAL ALEMU
    Background: Pulmonary Tuberculosis (PTB) is one of the most burdensome infectious diseases in the world. By the year 2022, 10.6 million people developed symptomatic tuberculosis disease and 1.3 million people died. Studies have shown that not only the lungs, but the disease also affects bone marrow and hematological abnormalities were reported. However, little is known about platelet profile of pulmonary tuberculosis patients in Ethiopia. Objective: To assess Platelet parameters among adult Pulmonary Tuberculosis patients at two health centers in NSC and LSC, Addis Ababa, Ethiopia. Methods: Institution based Comparative cross–sectional study was conducted among pulmonary tuberculosis patients. A convenience sampling technique, to recruit 156 PTB patients were newly starting treatment immediately after the diagnosis, among 156 PTB patients were 100 from woreda 02 and the rest was 56 from woreda 04. Also 104 apparently healthy individuals, 52 from woreda 02 and 52 were from 04 HCs. Socio-demographic data was obtained from structured, closed ended and pre tested questionnaires. Clinical data obtained from their medical records. Sysmex XP-300 and Weisman AC310 of woreda 02 and 04 HCs automated hematology analyzers that used for blood analysis. The data presented with words, tables, and figures and it analyzed by descriptive statistical tool, Epi-data V4.6.0.6 used for data entry, data transferred to SPSS version 20.0 for analysis, compared PTB versus control of platelet parameters with Pearson correlation and weight, independent t-test and Mann-Whitey U test compared the median value, P value 0.05). Regarding the magnitude of platelet abnormalities, 86(55%) had thrombocytosis and no thrombocytopenia was reported among PTB patients. The median of MPV and Platecrite values for PTB patients were slightly higher than the healthy control (10.00 ± 5.67 versus 9.3 ± 1.38 and 0.27 ± 0.07 versus 0.23 ± 0.07) respectively, then statistically significant difference (P < 0.05). In contrast, the median PDW of PTB patients were slightly less than the healthy control, however, it was not statistically significantly difference. Conclusion: This study demonstrated platelet indices such as platelet count, MPV and PCT values of PTB patients were higher but PDW was lower compared with healthy control. Thus, the clinicians could assess parameters for routine PTB treatment follow-up. Further studies are required to understand the role of platelet parameters for follow up and progress. Key words: Pulmonary Tuberculosis, Platelet parameter.