Browsing by Author "Abdulkadir,Halima"

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    Assessment of Liver and Renal Function Tests among Gasoline-Exposed Gas station workers in Addis Ababa, Ethiopia
    (Addis Ababa University, 2025-06) Abdulkadir,Halima; Wolde,Mistire(PhD, Associate Professor); Alem,Mekdes(MSc); Tsegaye,Aster(PhD)
    Background: Gasoline station workers are at a higher predisposition to exposure by benzene, toluene, ethylbenzene, and xylene, which can adversely affect liver and renal functions. However, there is a scarcity of wide-ranging studies focusing on the specific impacts of occupational gasoline exposure in the Ethiopian context. Objective: To assess Liver and renal function tests among gasoline exposed gas station workers compared to unexposed controls from February 2025 to May 2025 in Addis Ababa, Ethiopia Methods: Comparative cross-sectional study was conducted among gas station workers versus non – gasoline exposed control group from February 2025 to May 2025 in Addis Ababa, Ethiopia. It comprised of 146 gasoline exposed workers and 146 apparently healthy control groups. Based on a structured questionnaire, each study participants’ socio-demographic data was collected and afterward, five milliliters of blood sample was drawn into serum separator tubes. The samples were then transported to Ethiopian Public Health Institute’s laboratory for sample processing. Cobas c311 was used to measure the analytes. SPSS version 26 was used for statistical analyses – descriptive statistics to summarize the participant characteristics, independent t-tests, Mann Whitney U, One-way ANOVA tests, Kruskal Wallis test and multivariable logistic regression were employed to compare results among the groups. Result: From 292 participants, 146 Gas station attendants and 146 controls that were enrolled in this study. Gasoline Exposed workers showed significantly higher median ALT (12.4 vs. 7.8 U/L; p < 0.001), GGT (31 vs. 18 U/L; p < 0.001), ALP (64.0 vs. 61.0 U/L; p = 0.045), TBIL (0.37 vs. 0.30 mg/dL; p = 0.005), mean AST (19.77 vs. 18.44 U/L; p = 0.015), UA (5.91 vs. 5.16 mg/dL; p < 0.001), and Creatinine (0.90 vs. 0.81 mg/dL; p < 0.001), but no differences in DBIL or Urea. Employment >6 years increased GGT, TBIL, and DBIL; >8 hours/day and >6000 L/day elevated Creatinine, UA, and ALP Conclusion: Gasoline exposure impairs liver and renal function, likely due to benzene-induced oxidative stress. Overall, this thesis highlights the need for improved workplace safety practices, regular health checkups, and targeted interventions to reduce gasoline-related health risks