Browsing by Author "Abdu Hussen"

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    Two-Generation Reproductive Toxicity and Teratogenicity of 70% Ethanol Extract of Moringa Stenopetala (Baker F.) Cufod. Leaf In Rats
    (Addis Ababa university, 2024-01-09) Abdu Hussen; Tadele Ashenif
    The plant Moringa stenopetala (Baker f.) Cufod. (Moringaceae) is a fast-growing tropical plant that is consumed as a native vegetable in southwest Ethiopia. The leaves of the plant are used as the main food source and in folks medicine several ailments, including elevated cholesterol, diabetes, stomach pain, hypertension, malaria, and retained placenta removal. There is conflicting data available right now regarding safety and effectiveness of Moringa stenopetala. According to certain research, it stimulates follicular growth, ovulation, and spermatogenesis. However, other research reports its teratogenic and abortifacient effects, induction of embryonic resorption at late stages of pregnancy, damage to the seminiferous tubules and epididymis, and post-coital antifertility effects. These conflicting reports and a lack of sufficient information regarding the plant's teratogenicity and reproductive toxicity profiles led to the design of this experiment. It is therefore important investigating into how the Moringa stenopetala leaf affects fetal and embryonic development as well as reproduction. Consequently, the aim of the present study was to evaluate the toxic effects of Moringa stenopetala leaf extract on the developing rat embryos and fetuses. Furthermore, the study investigated the toxicity of the plant on the reproductive organs and serum biochemical profiles of F0 and F1 male and female Wistar albino rats, as well as the developmental status of their offspring (F1 and F2 pups).