Pharmacy Practice

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Browsing Pharmacy Practice by Author "Alebachew, Minyahil (B.Pharm, MSc, Assistant Professor of clinical pharmacy)"

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    Assessment of Drug Related Problems among Elderly Patients Visiting Menelik II Referral Hospital, Addis Ababa, Ethiopia
    (Addis Abeba University, 2020-06) Linger, Bedilu; Alebachew, Minyahil (B.Pharm, MSc, Assistant Professor of clinical pharmacy); Demessie, Samuel (MD, Internist); Mullu, Assefa(B.Pharm, MSc, Assistant Professor of clinical pharmacy)
    Drug therapy in the elderly needs an emphasis on the age related changes in drug pharmacokinetics and pharmacodynamics profile. As the age increase, people usually have more health problems that lead to the use of more medications than younger people do. Identification and prevention of drug related problems (DRPs) in geriatric outpatients will be an important step towards reducing hospital admissions. There are different studies regarding to DRPs in general population but studies regarding DRPs in elderly patients are scarce specifically in MIIRH there is no previous studies. This study aimed to assess DRPs among chronic elderly patients. A hospital based crosssectional study was conducted on 236 chronic elder patients who were on follow up-care at MIIRH. Data collection was done through patient interview and medical charts review. Epi data version 4.2 and IBM SPSS version 23 were used for data entry and analysis respectively. Descriptive statistics, cross-tabulation, univariable and multivariable binary logistic regressions were used and P < 0.05 was used to declare association. More than two-thirds of patients had two or more comorbid disease. The most common diseases encountered were hypertension (72.0%) and diabetes mellitus (56.7%). In this study, 740 medications were used with the mean number of drugs per day was 3.14 ± 1.658 per patient. ACEIs 121(50.8%), antidiabetic agents 94(39.5%) and CCBs 75(31.5%) were commonly prescribed class of drugs. Forty nine percent of patients encountered at least one DRP and 118 drug related problems were identified. The average number of drug related problems per patient was 0.5. Non-compliance (45.8%) %) and needs additional drug therapy (24.6%) were major DRPs identified. antidiabetic agents were the most frequent drug class involved in DRPs. From 740 medications, 122(16.5%) drugs were from beers medication list, where (44.1%) of participants were exposed at least to one potentially inappropriate medications. To conclude, there is high prevalence of DRPs and PIMs. Marital status, number of comorbidity and number of drug prescribed have significant association with the occurrence of DRPs.