Pharmacology

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Browsing Pharmacology by Author "ababula, Teferra(Professor)"

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    Antimicrobial susceptibility pattern of bacterial uropathogens and associated factors of urinary tract infection among pregnant women attending antenatal care clinic of hiwot Fana specialized university hospital, Harar, Eastern Ethiopia
    (Addis Ababa Universty, 2018-06) Workneh, Alemseged; ababula, Teferra(Professor)
    Antimicrobial susceptibility pattern of bacterial uropathogens and associated factors of urinary tract infection among pregnant women attending antenatal care clinic of hiwot Fana specialized university hospital, Harar, Eastern Ethiopia Alemseged Workneh Addis Ababa University,2018 Urinary tract infections(UTI) are the commonest bacterial infections during pregnancy, leading to significant maternal and prenatal mortality.Moreover, the changing pattern of antimicrobial susceptibility of bacterial uropathogens is another growing problem. Therefore, this study was aimed to determine bacterial uropathogens is another growing problem.Therefore, this study was aimed to determine bacterial uropathogens, their antimicrobial susceptibility pattern and associated risk factors of UTI anong pregnant women attending at ANC clinic of Hiwot Fana Specialized university Hospital, Harar, Eastern Ethiopia. Hospital based cross-sectional study was conducted from November, 2017-January,2018 on 200 conveniently selected pregnant. data collection involved face to face interview, urine culture,and antimicrobial susceptibility test. Statistical models such as bivariate and multivariate logistic regression were used to analyze the date. The overall prevalence of UTI was 15.5%. A total of 31 bacterial uropathogens were isolated. E.coli 45.2% was the most isolated Gram negative bacterial pathogen followed by proteus spp, 22.6% and K.Pneumoniae, 16.1%. Most of the isolated bacteria showed high level of sensitivity to amikachin 96.4%, nitrofurantoin, 90.3% and gentamicin, 83.9%. In contrast, resistance of 58.1% to ampicillin, 51.6% to each of augmentin and cotrimoxazole was obtained. Prior use of indwelling catheter(AOR:5.348, 95% CI: 0.984, 29.075), and having previous history of UTI(AOR: 5.624, 95% CI: 2.385,13.261). Were statistically associated with the occurrence of UTI among pregnant women. In general, the early identification of bacterial uropathogens and its antimicrobial susceptibility pattern will help in patient betterment and containment of the spread of resistant bacteria in this study area. As result the clinicians need to prescribe Antimicrobial agent after culture result and hospital should establish well equippe bacteriology laboratory for culture and antimicrobial susceptibility tests.