Pharmacology

Permanent URI for this collection

http://etd.aau.edu.et/handle/123456789/80

Browse

Browsing Pharmacology by Author "Abu, Duresa"

Now showing 1 - 1 of 1
  • No Thumbnail Available
    Item
    Prevalence of Asymptomatic Bacteriuria, Antimicrobial Susceptibility Pattern of the Bacterial Isolates and Associated Risk Factors among Pregnant Women Attending Antenatal Care (ANC)Clinic of Assosa General Hospital, Benishangul Gumuz Region, Western Ethiopia.
    (Addis Ababa University, 2019-12) Abu, Duresa; Prof.Abula, Tefera
    Background: ASB is a common problem in pregnant women and about 40% of women with untreated asymptomatic bacteriuria during pregnancy develop pyelonephritis, which might lead to low birth weight, preterm, premature rupture of membranes and preterm labour. Therefore, this study aimed to assess the prevalence of asymptomatic bacteriuria, antimicrobial susceptibility pattern of the isolates and related risk factors among pregnant women attending antenatal care clinic of Assosa General Hospital, western Ethiopia. Methods: A facility-based cross sectional study was conducted from January to February 2019. Data collection involved face to face interview and freshly voided midstream urine samples was collected from each study participants then urine culture and antimicrobial susceptibility tests was conducted. A total of 283 pregnant women were involved. Data was analyzed using SPSS statistical software version 20.0 and multivariate logistic regression analysis was used to determine the predictors and P-value. Result: The overall prevalence of ASB among pregnant women in this study was 14.85%.E. coli was the most predominant isolate (50 %,) followed by K. pneumoniae (16.7%,), S. aureus (14.3%), coagulase negative staphylococci (CONS) (11.9%), and group B streptococci (GBS) (7.1%).Gram-negative bacteria were highly resistant for tetracycline (96.4%), ampicillin .Gram-positive bacteria were 100% sensitive for ceftazidime. In multivariate logistic regression, educational status [illiterate (AOR=14.7; 95%CI: 4.06-52.63), without formal education (AOR=9.8; 95%CI: 2.81-34.78)], gestational age [1st trimester (AOR=6.76; 95%CI: 1.81-25), 2nd trimester (AOR=6.9; 95%CI: 2.0-23.81)], history of UTI (AOR: 3.46; 95%CI: 1.48-8.1) and history of catheterization (AOR: 4.1; 95%CI:1.7-10.2) were significantly associated with asymptomatic bacteriuria. Conclusion: Significant bacteriuria was observed in asymptomatic pregnant women. Therefore, routine laboratory diagnosis of ASB in pregnant women and providing appropriate treatment should be needed to reduce its complications. Increasing antibiotic resistance complicates empirical regimens and local resistance rates need to be taken into consideration when deciding on therapy.