Neurology

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Browsing Neurology by Author "Ayalew Moges"

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    Neonatal Seizure Pattern, Short-Term Outcomes and Predictors Among Nicu Admissions in Ethiopia: A Multicenter Cross Sectional Prospective Study
    (Addis Ababa University, 2025-09-02) Tazebew Tilahun; Ayalew Moges; Behaylu Yibe; Jemal Haidar
    Background: During neonatal period seizure is one most common presentation .Presentation and type is different from elder children.It have high risk of mortality as well as morbidity with high risk of neurological impairment or future epilepsy. Hypoxic-ischemic encephalopathy, meningitis,hypoglycemia,and hypocalcaemia account the majority causes of neonatal seizure .However little is investigated about outcomes of neonatal seizure in Ethiopia . Objective: To describe neonatal seizure pattern, short term outcomes and its predictors among neonates with seizure admitted to NICU’sofTikur Anbessa Specialized Hospital, Yekatit 12 and Gandhi memorial hospital, AddisAbaba,Ethiopia. Methodology:A Multicenterinstitutional-based cross sectional prospective study wasdone among newborns with neonatal seizure admitted to Tikur Anbessa Specialized Hospital, Yekatit 12, and Gandhi Hospital from January 1 ,2025toSeptember 1, 2025.Data were collected using an adopted form of standard with pretested, structuredquestionnaires. Data were entered using SPSS version 27 and analayed with SPSS 27 after checking for missing values .Descriptive statistics like mean, median and mode were used to summarize descriptive data. Bivariate and multivariate logistic regression analysis were performed and variables with p-value of < 0.25 were included for multivariate logistic regression. Adjusted Odds Ratios (AOR) with 95% confidence interval were estimated to identify the strength of association. Statistical significance was declared at a p-value <0.05. Results:All of neonates with neonatal seizure were included with 100% response rate .The study found that 30 (27.8%) (95% CI: 22.2, 36.9) had poor neonatal seizure short-term outcomes. The study revealed that low 5th minute APGAR score (AOR=15.8, [95% CI: 1.06, 23.6]), history of neonatal resuscitation (AOR=6.58 [95% CI: 1.25, 34.6]), presence of prolonged labor (AOR=5.92, [95% CI: 1.13, 30.8]), and multiple episodes of seizure attacks (AOR= 11.3 [95% CI :1.73, 47.9]) were predictors of poor neonatal seizure outcomes. Conclusion:More than one-fourth of neonates with seizures experienced poor neonatal seizure outcomes. Low5th minute APGAR scores, a history of neonatal resuscitation, prolonged labor, and multiple episodes of seizure were predictors of poor neonatal seizure outcomes. This finding emphasizes the critical need for correcting these risk factors. A coordinated effort by various stakeholders is essential to implement strategies that improve neonatal seizure outcomes.