The purpose of this study was to assess the linkage between Chagni TVET institutions and MSEs in Awi Zone of Amhara National Regional state. The approach used in this research was a mixed approach which makes the use of both quantitative and qualitative description. To this end, questionnaire and interview tools of data collection were employed. The information gleaned through questionnaire from a sample of 30 trainers, 220 trainees and 380 operators. Face-to-face interviews were conducted with head of collage, head of MSE and head of MFI. The respondents of trainers, trainees and operators were selected using random sampling technique. While the interview questions were selected using purposive sampling techniques. Thus, the collected data were tabulated, presented and analyzed by using frequency and percentage distribution. The empirical study obtained that, there is a weak linkage between TVE and MSE sectors. Since (98.7%) respondents responded, there is no policies implementation on the ground in case of linkage, the relevance of curriculum with labour market is unfit and government support is poor. Based on the major findings, it could be concluded that there is a weak linkage between TVET and MSE sectors. To suggest that, there is a need for the endorsement of linkage policy as guidelines for implementing in both sectors to strengthening the partnership between TVET institution and MSE organizations, improving career guidance as necessary mechanism for helping students to select a marketable field of study and operators to strengthen their work effectively and producing the standardized curriculum that fits with the current markets