Yonas GirmaHidaya Yahya2025-08-122025-08-122024-02-13https://etd.aau.edu.et/handle/123456789/6484Background: Breast cancer is the most common cancer in Ethiopia with an estimated incidence of 16,133 new cases and 9,061 deaths in 2020. Patients with breast cancer are frequently observed experiencing locoregional recurrences despite the many treatment options available. The purpose of this research was to determine the incidence and recurrence predictors among patients with breast cancer at Tikur Anbessa Specialized Hospital, Ethiopia. Methods: An institution-based retrospective study was conducted from November to December, 2023. 258 patients who had surgical treatment for breast cancer from September 11,2017 to September, 10, 2020 were included in this study. Data were collected from the patients charts by using Kobo toolbox. The collected data was analyzed using SPSS version 26. Median time to recurrence was determined, and life tables were used to determine recurrence free survival time and the proportion of survival over a follow-up period. The assumptions of cox proportional hazard were checked, and variables were analyzed in bivariate and multivariable Cox proportional hazard model. Adjusted Hazard Ratio (AHR) with 95%CI was calculated for the significant predictive variables and statistical significance was declared at p-value. Result The incidence rate of breast cancer recurrence was 5.36 per 100 person-years (95%CI=3.85-7.07) follow-up. The median Recurrence Free Survival (RFS) time was 55 months (95CI%=41.73 68.26). The proportion of RFS at 12, 24 and 60 months were 92.5%, 81.4% and 41.7% months respectively. Histologic grade 3 (AHR=3.22, 95% CI (1.37, 7.6)), and lymph node involvement (AHR=1.175, 95%CI, (1.11,1.27)) were independent predictors for increased risk of breast cancer recurrence. Conclusion There is high incidence of locoregional recurrence in breast cancer patients. Applicable pathological variables including histologic grade and lymph node positivity may predict the likelihood of a breast cancer recurrence and should be emphasized in breast cancer care.en-USClinicopathological factors associatedThesis