Tsegaye AsterAlemu JemalTamir ZemenuBelay Benyam2020-05-212023-11-062020-05-212023-11-062019-06http://etd.aau.edu.et/handle/123456789/21269Background: The presence of blood borne infections in blood cells or plasma ofasymptomatic donors is the major risk factors for transmitting infectious agents throughblood transfusion.Common infectious agents include Hepatitis B virus,Hepatitis C virus ,Human immunodeficiency virus and Syphilis . Objective: To determine prevalence of transfusion transmissible infections ,ABO bloodgrouping and Antibody screening among blood donors at Defense Health MainDepartment Bella Blood Bank center of Addis Ababa, Ethiopia. Methodology: A retrospective study on the magnitude of TTIs among blood donors wasconducted from January2010 to April2019 at Defense Health Main Department BellaBlood Bank center Addis Ababa, Ethiopia. The socio-demography, TTI, ABO typing andantibody screen data was first entered into Excel spread sheet from the institutions file byremoving any identifier, cleaned and then finally exported to SPSS Version24 softwarefor analysis.Proportion and P-value was used to calculate statistical significances.P-value<0.05 was considered as statistically significant. Result: The overall prevalence of TTI was 99(10.8%) out of 927 voluntary donors.The prevalence is 93(11.8%)in male and 6(4.2%) in Female. Majority affected agegroupwere 46-58(16.4%) followed by 36-45(10.4).The prevalence of HIV,HBV, HCV andSyphilis was 8(0.9%),46(5%),23(2.5%)and 22(2.4%) respectively.Five out of 927(0.53%)had multiple infections, the most common combinations were HBV-HCV 2(0.21%),HBV-Syphilis 2(0.21%) and Syphilis-HCV 1(0.1%). Antibody screening profile revealed1(0.1%)positive. Conclusion: Th e overall prevalence of TTI was 10.8. promoting of health educationamong the donor community and enhancement of voluntary donation is recommended.en-USTTI, ABO,Antibodyscreen,voluntary blood donors.Thesis