Murugan,Rajalakshmi (PhD,Associate professor)Admasu,Mekonnen (Lecturer)Berhanu,Bezawit2023-12-132023-12-132023http://etd.aau.edu.et/handle/123456789/883Background: - Oxygen is one of the most essential medications. Oxygen therapy is a medical procedure used to treat tissue hypoxia. It has the potential to improve medical outcomes and save lives when used correctly, but it can also cause harm when wrongly used. However, there is limited evidence on nurses’ knowledge of oxygen therapy in the study area. Therefore, this study fills the research gap. Objective: The objective of this study is to assess the knowledge and practice of oxygen therapy and its associated factors among nurses working in a paediatric unit in selected hospitals in Hawassa. Method: - An institutional-based cross-sectional study design was employed during February 27–March 27, 2023 in six selected hospitals among 174 nurses working in paediatric units. A simple random sampling technique and self-administered structured questionnaire was used for data collection. Data was entered and analysis was done with Epi-data 3.1 and SPSS v26, Frequency and percentages were expressed in texts, tables, and charts, whereas logistic regression was conducted to check the association of dependent variables with factors and variables. A p-value ≤ 0.05 in multivariate analysis was considered significant in the 95% CI. Results: The ages of the study subjects were in the range of 23–49. The mean age was 30.6 (SD = 4.8 years). The knowledge and practice levels of the study participants in oxygen therapy were 55.7% and 51.1%, respectively. The factors associated with knowledge of oxygen therapy among nurses were educational level of degree [AOR: 0.108; 95% CI (0.012– 0.98)] and training [AOR: 4.07; 95% CI (1.8–9.2)] and practice being diploma [AOR: 0.04; 95% CI (0.004–0.05)], training [AOR: 3.77; 95% CI (1.48–96)] were significantly associated factors in the p value of less than 0.05. Conclusion: The knowledge and practice level of nurses towards oxygen therapy were poor. Therefore, this study recommended that nurses who are all working in paediatrics units must receive training to update the KP oxygen therapy.en-USKnowledge, Practice, Oxygen Therapy, Nurses, Paediatrics unitThesis