Genet TeferYoseph LegesSamrawit Admassu2026-04-032026-04-032025https://etd.aau.edu.et/handle/123456789/8028Psoriasis is a common chronic inflammatory disease characterized by skin inflammation and epidermal hyperplasia. Psoriasis can significantly impact a person's quality of life. Physical discomfort, such as itching, and pain, can interfere with daily activities. The visible nature of the condition can lead to emotional distress, social stigma, and mental health issues like anxiety and depression. People with psoriasis are also at a higher risk for other health conditions, such as psoriatic arthritis, cardiovascular diseases, and mental health issues. Understanding psoriasis and its wide-ranging effects on individuals is essential for providing effective care and improving the lives of those affected by this chronic condition Objective: This study aimed to Quality of life and its Determinants among psoriasis patient at ALERT hospital, Addis Ababa Ethiopia Methods: A hospital-based cross-sectional study was conducted at ALERT Comprehensive Specialized Hospital, Addis Ababa, from May to August 2025. A total of 128 patients aged 16 years and above with a confirmed diagnosis of psoriasis and at least six months of follow-up were included using consecutive sampling. Data were collected through face-to-face interviews using a structured questionnaire and the Dermatology Life Quality Index (DLQI). Sociodemographic and clinical data were recorded. Data were entered and analyzed using SPSS version 27. Due to non-normal distribution of DLQI scores, non-parametric tests (Mann– Whitney U, Kruskal–Wallis H, and Spearman correlation) were applied. Statistical significance was set at p < 0.05. Result: The median DLQI score was 13 (IQR: 9–18), indicating a very large impact of psoriasis on quality of life. More than half of the patients experienced very large to extremely large impairment. Poor quality of life was significantly associated with older age, marital status, social drug habits, family history of psoriasis, early age at diagnosis, pustular psoriasis, and involvement of functionally or socially sensitive sites such as extremities, genitals, palms, soles, and nails. Disease duration, sex, educational status, income level, and most comorbidities showed no significant association with quality of life. Conclusion: Psoriasis has a substantial negative impact on the quality of life of patients attending ALERT Hospital, even among those with mild clinical severity. Quality of life VIII impairment was influenced more by disease characteristics and lesion location than by sociodemographic factors. Routine assessment of quality of life and integrated clinical and psychosocial management approaches are essential to improve patient outcomes.enQuality of lifePsoriasisALERTEthiopiaThesis