Dr. Ashenafi, HagosBerihun, Abebe2018-06-282023-11-082018-06-282023-11-082015-10http://etd.aau.edu.et/handle/123456789/4373A cross sectional study was conducted in two purposively selected central low land Oromia regions Boset districts (intervention area) one of the project operational areas of Donkey Health and Welfare Project (DHWP) and AdametuluJidoKombolcha districts (control area) agroecological from December 2014 to mid July 2015. The study was carried out in different seasons (dry and beginning of the rainy seasons). The objectives of the study were to determine prevalence of nematode parasites, identifications of non-nematode parasitic health related problems and evaluation of animal owner perception on strategic mass deworming of donkey with ivermectin. Faecal samples were collected randomly from 580 (intervention area) and 771 (control area) working donkeys and subjected to parasitological examination including simple flotation, McMaster egg counting technique and faecal culture. The overall prevalence of major nematode parasites were Cyathostomum ( 81.7% and 100%) , Strongylus vulgaris(68.3% and 97%), Trichostrongylus axei (62.2% and 92.5%),Dictyocaulus arnfieldi (21.2% and 49.4%), Parascaris equorum (15.9 % and 23.6%) and Oxyuris equi (7.6% and 10.4%) in intervention and control areas , respectively (p˂0.05). The mean eggs counts of Strongylus revealed (304.6 and1293.00) during dry season and (307.32 and 1456.53) during the beginning of rainy season in intervention and control areas, respectively (P˂0.05). The impact of strategic mass deworming in the intervention area also revealed lower number of nematode parasites, species and epg of Strongylus in intervention area as opposed to the control area. There was no statistical significance difference (p˃0.05) in O.equi, body conditions and visible mucus membrane in both study areas. Among non nematode parasitic health related problems, knits of Gastrophilus (31.9% and 32.7%) and abnormal mucus membrane (31.9% and 32.7%) were major between control and intervention areas, respectively Based on these, it can be concluded that parasite burden and faecal egg counts were lower in intervention area as opposed to control area. Taking into account the existing health problems of working donkeys in both areas coupled with current trend in strategic mass deworming of donkeys, alternate use of the anthelmintics with supplementary feeds, improved management practices and efficacy study of ivermectin and study of the relationship of faecal egg counts with parasite burden were recommended. Key words: Assessment, Control area, Ethiopia, Ivermectin, Impact, Intervention area, Nematode, Oromia, Prevalence, Strategic mass demormingenAssessmentControl areaEthiopiaIvermectinImpactIntervention areaNematodeOromiaPrevalenceStrategic mass demormingThesis