Tadesse, Yewondwossen (internist, consultant Nephrologist)Dr.Melkie, Addisu(internist, consultant Nephrologist)Yalew, Eyerusalem2022-02-282023-11-052022-02-282023-11-052021-10http://etd.aau.edu.et/handle/123456789/30378Background: acute kidney injury and worsening of renal function is common in patients with acute decompensated heart failure, and development of this entity affects patient’s morbidity and mortality. Objectives: The main objective of this study was to assess the prevalence, and associated factors for development of WRF in admitted ADHF patients. Methods: This was a prospective, hospital-based study of cardiac patients admitted to TASH between June, 2021 and October, 2021. A structured questionnaire was used to collect parameters on sociodemographic characteristics, comorbidities and clinical profile of patients. Trained physician data clerks collected the data from the chart, interview and electronic medical records. Data was entered into SPSS version 26 for analysis. Bivariate and multivariate binary logistic regression analyses was done to identify factors associated with AKI and WRF, Statistical significance was considered at the level of significance of 0.05%, and adjusted odds ratio (AOR) with 95% confidence interval (CI) was used to present the estimates of the strength of the association. Result: A total of 104 patients were included in the study. 64(61.5%) were male and 40(38.5) were female. The prevalence of AKI was 21.2% and the prevalence of WRF was 37.5%. The odds of developing AKI in smokers was 3.7 times higher [AOR= 3.7; 95% CI: (0.86, 13.18)]. Conclusion: This study demonstrated that WRF is frequent finding complicating management of ADHF patients.en-USThesis