Urgessa, Fekadua (Ph.D. fellow)Tibebu, Melatwork(Ph.D. fellow)Abebe, Hanna2024-11-282024-11-282023-02https://etd.aau.edu.et/handle/123456789/3786Background: Diabetes Mellitus has been growing as a worldwide health problem. Platelet indices such as platelet count, mean platelet volume, platelet distribution width and plateleticrit are indicators of platelet hyperactivity and can be used as early markers for diabetic complications. Objective: To assess platelet parameters among Type II Diabetic Mellitus patient at Addis Ketema Woreda 3 health center, Addis Ababa, Ethiopia, from June to December 2021. Method: A comparative cross-sectional study was used and involving 255 participants consisting of 85 diabetic and 170 non-diabetic controls was conducted from June to December/2021 G.C and convenient sampling technique used. About 3-4ml blood sample from each participant was collected into a test tube (purple cap) containing EDTA for complete blood count measurement on Mindray BC3000 hematology analyzer. Data was collected, entered, & analyzed using SPSS version 25 software. The mean and standard deviation was used to summarize platelet parameters. One-way ANOVA (analysis of variance) were done to compare the platelet parameters difference across the two groups (DM Type II & Control), and A P-value of <0.05 is considered as statistically significant. Result: A total of 255 study participants was involved on the study. Out of the total 85 case were included in the study among them 47/85 (55.3%) were female and the mean age of participant was 47.4±13 years. Based on HbA1c values the pattern of glycemic control among diabetic patients was determined, majority of participant 75.3% had poor glycemic control. The platelet count, mean platelet volume, and plateletcrits decreased between patients with diabetic mellitus than control group (P=0.001). Platelet count, mean platelet volume, and plateletcrits parameters significantly different and correlated were case group of participant with HbA1c >6.5% (P<0.05). Conclusion: Majority of diabetic subjects are poor glycemic control or HbA1c level greater than 6.5% were 75.3%. In this study platelet count, mean platelet volume, and plateletcrits significantly differences between diabetic’s subject compared to non-diabetics subjects but a platelet parameter value there is no difference between Diabetic with complications and without complication participant.en-USType 2Diabetes Mellitusplatelet countMean Platelet VolumePlatelet Distribution WidthPlateleticritPlatelet parametersEthiopia.Thesis