Argaw, Zeleke( BSC, MSC, Ass. Professor)S/r.Berhane, Emebet(BSC, MSC (PhD fellow)Adugna, Girma2021-11-052023-11-052021-11-052023-11-052021-06http://etd.aau.edu.et/handle/123456789/28525Background: Cytotoxic extravasation is the major adverse effect than the combinations of sepsis, neutropenia, mucositis and gastrointestinal disorders. Pain, immobility, irreversible damage of nerve, tissues and tendon, skin grafting and loss of extremity are the significant morbidities secondary to extravasation. Objective: The aim of this study was to assess nurse’s knowledge and associated factors towards prevention and management of cytotoxic extravasation in selected public hospitals, Addis Ababa, Ethiopia, 2021. Methods: A descriptive cross-sectional study design was conducted at Tikur Anbessa Specialized Hospital and Saint Paul Hospital Millennium Medical College that was selected purposely. A convenient sampling technique was employed for the selection of study participants. The data was collected by using a structured self-administered questionnaire. The data entry and cleaning was done by using Epi-data version 4.6 and SPSS version 25. Logistic regression analysis technique was employed to evaluate the effect of independent variables on the dependent variable. Statistical significance was declared with the p</=0.05. The data description was presented in text, tables and graphic representation. Result: A total of 124 nurses voluntarily participated in the study with a response rate of 93.2% and 58.1% were female nurses. Majority (45.2%) of study participants are from the age group of 20-29 years. The mean (±SD) age was 31.86 (±5.987) years. 34.7% of respondents had a good levels of knowledge in the way to prevent and manage cytotoxic extravasation. Nurses who got training were 6.6 times more likely to have good knowledge of prevention and management of cytotoxic extravasation; [AOR= 6.602 (2.705-16.109)]. Conclusion and recommendation: Generally 65.3% of study participants had poor knowledge towards prevention and management of cytotoxic extravasation. High number (66.9%) of nurses are not trained on cytotoxic extravasation. Supporting nurses working in cancer centers with continuous training programs to enhance their knowledge on extravasation should be a primary task.en-USNurses, cytotoxic extravasation, knowledge, prevention, management.Thesis