Tamrat Abebe;Seifegebriel Teshome2025-08-122025-08-122024-06-13https://etd.aau.edu.et/handle/123456789/6478The Epstein-Barr virus (EBV) is a member of the herpesvirus family and is highly prevalent among the global population. It is estimated that more than 90% of adults have been exposed to this virus, making it one of the most common human viruses worldwide. After initial infection, infectious mononucleosis (IM), which typically occurs during childhood or adolescence, EBV establishes a long-lasting latent infection within B lymphocytes. EBV is associated with various diseases such as Burkitt's lymphoma, Hodgkin's lymphoma, nasopharyngeal carcinoma, and certain types of Gastric cancer. Studying the overall viral molecular epidemiology and genetic diversity of EBV can provide valuable insights into the pathogenesis, diagnosis, and management of EBV-associated diseases. The objectives of the study were on various aspects of EBV among lymphoma patients. It encompasses the detection of EBV, determining the genotypes, analysis of its methylation status, and identification of sequence variationsen-USMolecular Epidemiology and GeneticThesis