Ermias GizawAyenew Mulualem2025-08-072025-08-072024-10-10https://etd.aau.edu.et/handle/123456789/6203Most cancer deaths are not due to primary tumors rather as a result of the metastatic events. Patients with bone metastasis may experience skeletal complications, such as pathological fractures, hypercalcaemia, neurologic symptoms and uncontrolled pain requiring bone surgery and/or radiotherapy, which are collectively called skeletal-related events (SREs). These skeletal related events seriously affect patient’s quality of life and contribute to the poor prognosis of patients. The purpose of this study was to assess the profiles of metastatic bone disease among patients with systemic malignancies and the determinant factors which affect patient’s quality of lifeen-USMetastatic bone diseaseskeletal related eventsvisceral metastasisECOGThesis