Abula, Tefera (PhD, Professor)Simeneh, Taklo2018-12-042023-11-062018-12-042023-11-062018-02http://etd.aau.edu.et/handle/123456789/14790Reduced kidney function in tenofovir disoproxil fumarate based regimen and associated factors: A hospital based prospective observational study in Ethiopian patients Taklo Simeneh Addis Ababa University, 2018 Tenofovir Disoproxil Fumarate (TDF), a drug broadly used in combination antiretroviral therapy (cART), is associated with renal dysfunction but the prevalence varied from country to country and it is not known in Ethiopia. TDF has been in use in Ethiopia since 2014. The objectives of this study were to assess prevalence of renal dysfunction and risk factors associated with it and the mean change in estimated glomerular filtration rate (eGFR) in human immunodeficiency virus (HIV) infected patients receiving TDF based antiretroviral regimen at Tikur Anbessa Specialized Hospital (TASH). It was a hospital based prospective cohort study. The study participants were treatment naïve HIV infected patients initiating TDF containing combination antiretroviral therapy or switched to because of adverse events. Multivariable logistic analysis was used to identify variables which have significant association. Total of 63 study participants were studied, 16 (25.4%) of whom had greater than 25% fall in eGFR relative to baseline. Only age greater than 50 years old, CD4 count less than 200cells/mm3, and proteinuria were significantly associated with renal dysfunction in multivariable logistic regression. There was -8.4 ml/min/1.73m2 mean change in eGFR relative to baseline at six month of study. In conclusion, the renal dysfunction (defined as greater than 25% decline in eGFR) was found in a quarter of the study population. The long term impact and the clinical implication of it are not clear. Future prospective study is required with large sample size and long duration to ascertain the prevalence of acute kidney injury (AKI) and its progression to chronic kidney disease (CKD).en-USTenofovir Disoproxil Fumarate (TDF), TDF based antiretroviral regimen, renal dysfunction.Thesis