Tsegaye, Aster (MSc, PhD, Associate Professor)Kinde, Samuel (MSc, PhD Candidate)Challa, Feyissa(MSc, PhD Candidate)Getahun, Tigist2021-01-032023-11-062021-01-032023-11-062020-07http://etd.aau.edu.et/handle/123456789/24520Background: HbA1c and fructosamine used for diabetes monitor and control as a glycemic control. The absence of locally derived referenc intervals for these parameters from apparenetly health subjects for the local will impact on the physician, laboratories, and researchers. Objective: to establish reference interval for hemoglobin A1c and fructosamine for apparently healthy adults in Addis Ababa, Ethiopia. Methodology: A cross sectional study was conducted in four selected sub-cities (Akaki, Kirkos, Arada, Yeka), Addis Ababa, Ethiopia from December 2019 to April 2020. The study was including study participants with 18 and above years of age. Blood sample was collected and analyzed by using Cobas 6000(c 501) instrument. Both Kolmogorov–Sminorv, and MannWhitney test were analyzed to check the data normality distribution and partitions, respectively. Reference intervals, lower 2.5 th percentile and 97.5 th percentile for the upper, (overall, and specific for sex and age) were determined using non-parametric methods. Result: - Out of the total 344 participants, 256 (121 males, 135 females,) study participants aged 18-60 years participated in this study. Reference interval was established from 4.70 – 6.27% and 203 - 321mol/L for HbA1c, and fructosamine, respectively. There was weak association between HbA1c and age (r=0.1803, p=0.0378). Conclusion: This study established reference intervals for both HbA1c and Fructosamine for adult population using the current available equipment platform. The established reference interval is applicable for the current practice in the country to diagnosis, treatment, and monitor of diabetics mellitus.en-USHemoglobin A1c, fructosamine, reference interval, Ethiopia.Thesis