Dr. Fikru Regassa, Dr. Fufa AbunnaMr. Takele BeyeneAbebe, Bulcha2018-09-242023-11-082018-09-242023-11-082018-06http://etd.aau.edu.et/handle/123456789/12162A thesis submitted to the college of veterinary medicine and agriculture Addis Ababa University in partial fulfillment of the requirements for the degree of Master of Science in veterinary epidemiologyFor the present study questionnaire survey, cross-sectional and experimental trials were carried out from January - May 2018: to assess the problem of bovine trypanosomosis, to determine the prevalence of bovine trypanosomosis; to assess trypanocidal drug resistant and to evaluate the effectiveness of herbal remedies extracted used for the treatment of bovine trypanosomosis. Stata version 12 was used to analysis data collected from the fled and laboratory. For the questionnaire survey 80 individuals were interviewed, focused on the constraints of trypanosomosis in the area. For parasitological survey, blood samples of 430 cattle were examined using buffy coat technique and wet blood smear. The packed cell volume (PCV), of animal sampled on field and in laboratory animals were recorded using hematocrit reader. The level of parasitaemia, body weight, packed cell volume and mean survival period of experimental animals were monitored. The overall prevalence of trypanosomosis in the study area was found to be 7.44% (P = 0.023). The mean PCV value (%) of parasitaemic and aparasitaemic animals during the study period were 23.12% and 26.55% respectively, which is statistically significant (p<0.05). H.villosa chloroform extracted given at a dose of 600 mg/kg bw, reduced parasitaemia 24.6+8.45 (p < 0.05). The in vivo drug resistance tests indicated the presence of resistant parasites with the normal dose against DA isolate and suspected resistance problems were detected against ISM and DA for and isolates respectively. It was concluded that the present work evidenced that trypanosomosis has continued to pose a considerable threat to cattle production in the study area warranting an integrated control and prevention to safeguard cattle production and productivity. Therefore, trypanosomosis is a major animal health problem in study area and drug resistance is a threat in the control of trypanosomosis in both study areas. The search for alternative compounds against African trypanosomosis is justified by various limitations of existing chemotherapeutic agents. Efforts should also be directed at evaluating the possible benefits of natural products in trypanosomosis treatment.enH.villosaprevalence,trypanosomosisThesis