Gedif, Teferi (B.Pharm, MPH, PhD)Gebrehiwot, Selamawit2018-11-302023-11-062018-11-302023-11-062018-09http://etd.aau.edu.et/handle/123456789/14715Background: Breast cancer is the most common cause of mortality and morbidity in Ethiopia. So far, the focus has been on clinical management of cancer but nowadays, health-related quality of life (HRQoL) is emerging as an important health outcome. Hence, evaluating the HRQoL and utility is relevant to monitor patient treatment outcome and determine their quality adjusted life year’s gains to be used for economic evaluations. Objective: To assess HRQoL, influencing factors, and utility among patients with breast cancer at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. Methods: Hospital-based cross-sectional study was conducted among 404 women with breast cancer from December to February, 2018. The Amharic version of European Organization for Research and Treatment of Cancer-Breast Module, European Organization for Research and Treatment of Cancer, Euro Quality of Life Group’s 5-Domain Questionnaires 5 Levels and Euro Quality of Life Group’s visual analog scale instruments were used to collect the data. The HRQoL data was analyzed using SPSS version 23 while Microsoft Office Excel 2010 was used to analyze the utility score. Mean difference among independent were analyzed using one way ANOVA, Kruskal-wallis-test and Mann-whitney u test. Multivariable logistic regression was employed to assess the possible predictors of HRQoL. Results: The mean age of patients was 43.94 ± 11.72 years with majority (35.1%) of them on cancer stage 3. The mean score for global quality of life (GQoL) and visual scale analog was 59.32±22.94 and 69.94 ± 20.36, respectively while their mean utility score was 0.8 ± 0.25.The possible predictors of HRQoL were found to be stage of cancer (AOR= 7.94; 95%CI: 1.83-34.54), cognitive functioning (AOR=2.38; 95%CI: 1.32-4.31), pain (AOR=7.99; 95%CI: 4.62-13.83), financial difficulties (AOR=2.60; 95%CI: 1.56-4.35), and future perspective (AOR=2.08;95%CI: 1.24-3.49). Conclusions: The GQoL of patients from the present study was comparable to other studies and the utility mean score was estimated to be above average.en-USBreast cancer, Health related quality of life, HRQoL, Utility, EQ5D-5L, EORTC-QLQ-C30, EORTC-QLQ-BR23, Ethiopia.Thesis