Gutet,Senbeta(MD,MPH,Prof.)Ayanaw,Daniel2025-08-122025-08-122024-02https://etd.aau.edu.et/handle/123456789/6504Background: Coronary artery disease is a major cause of morbidity and mortality in developing countries with occurrence at a young age and association with diverse cardiovascular risk factors. Objective: The objective of this study was to assess the magnitude of premature coronary artery disease and its associated factors among patients who underwent coronary angiography at Tikur Anbessa Specialized Hospital (TASH), Addis Ababa, Ethiopia. Method: A retrospective cross-sectional study was conducted at TASH, Addis Ababa, Ethiopia, on 218 patients who underwent coronary angiography between May 2017 and June 2023. Data on patients’ sociodemographic characteristics, cardiovascular disease risk factors, metabolic profile, cardiac imaging, and angiographic findings was collected using a structured data abstraction checklist from patient medical records. Descriptive statistics and logistic regression were used to assess the association between dependent and independent variables using SPSS version 25. An adjusted odds ratio with a 95% confidence interval was used to show the strength of the association, while a p-value<0.05 was used to declare the significance of the association. Result: A total of 218 patients’ medical records were analyzed and revealed a median age of 55 years with male predominance (82.1%). Forty (18.3%) of patients were diagnosed to have premature coronary artery disease (CAD) among a hundred fifty-eight (72.5 %) patients who had angiographically confirmed CAD. Male sex (AOR=3.5, 95%CI: 1.492,8.367), hypertension (AOR=2.8, 95% CI: 1.162,6.767), low HDL (AOR=2.3, 95% CI:1.025,5.191) and admission diagnosis of chronic coronary syndrome (AOR=2.2, 95% CI: 1.035,4.762) were significantly associated with premature CAD. Conclusion: The magnitude of premature coronary artery disease at TASH is high. It is significantly associated with male sex, hypertension, low HDL, and admission diagnosis of chronic coronary syndrome. Tremendous effort should be applied to preventing, early detection, and control of hypertension and Low HDL at the community and individual level.en-USPremature Coronary Artery DiseaseCoronary AngiographyMagnitude.Thesis