Sisay, Abay (PhD, Ass. Prof.)Hassen, Fatuma (Ass. Prof.)Benti, Haile (PhD cand)Eshetu, Selam2026-01-302026-01-302025-10https://etd.aau.edu.et/handle/123456789/7613Background: Laboratory errors have potential to cause harm and be fatal so reduction of errors, which is the idea of Six Sigma, is essential. From internal quality control and external quality control data coefficient of variance, bias and total allowable error will be extracted and calculate sigma metrics. There is lack of sufficient knowledge about methodology, process and implementation of Six Sigma. Objective: The study aim to evaluate and assess professional perspectives toward implementation of Six Sigma metrics in Clinical Chemistry Tests at selected hospitals, Addis Ababa, Ethiopia 2024/2025 Methods: A cross-sectional study was conducted from January to April 2025. A judgmental sampling method was used to select hospitals and laboratory tests were included in the study. In depth interview was used for qualitative method. A self-administered questionnaire was used to collect data regarding the socio-demographic characteristics, knowledge and attitude of the participants. After verifying the completeness, data were coded, entered into SPSS version 25 for analysis. Microsoft Excel record sheet was used to collect daily IQC and recent EQA data for 10 tests and analysis done on excel for quantitative method Descriptive statistics were computed.Result: sigma metrics was evaluated for 10 tests in Hospital A and 9 tests in Hospital B. Totally 12(60%) at Hospital A and 18(100%) at Hospital B tests had unacceptable/ poor sigma metrics. Cobas 6000 have better sigma metrics than Beckman coulter DXC 700 based on six common tests. A total of 37 staffs was participated. Majority of participants 13(68.4%) at Hospital B and 13(72.2%) at Hospital B have first degree. Only 12(32.4%) of professionals answer above mean. We obtained 18 (48.6%) professionals have positive attitude toward six sigma method. Conclusion: Continuous process improvement was required for majority of tests. Manager commitment, formal training program, adequate staff with good knowledge and attitude, self-motivation and financial issues were challenges for not implementing of six sigma method.en-USsix sigmainternal quality controltotal allowable errorsix sigma in healthcareThesis