Ahmed AbdurezakBeyene Eyerusalem2021-02-032023-11-052021-02-032023-11-052020-06http://etd.aau.edu.et/handle/123456789/24936BACKGROUND-Prolactinomas are the most common type of pituitary adenomas in both sexes with different age distribution.They are benign neoplasms accounting for approximately 40% of all pituitary tumors. They are classified into two main groups based on the size of pituitary tumour at presentation: microprolactinoma (tumour diameter 1 cm). The clinical presentation of prolactinoma includes manifestations relating to hyperprolactinaemia and features relating to tumor bulk. OBJECTIVE- The objective of this study is to assess the clinical profile, diagnosis and treatment response of patients with prolactinoma on follow up at endocrine clinic of TikurAnbessa specialized Hospital (TASH). METHOD; Ahospital based retrospective cross sectional study was conducted on adult patients with confirmed prolactinoma attending Endocrine clinicof TASH from June, 2015 to June 2020. All patients with prolactinoma on follow up at endocrine clinic of TASHon the stated period were included. Data collection was conducted by the principal investigator from the charts and electronic medical records of patients using a structured questionnaire. Data was cleared and entered to IBM SPSS version 26. Result was processed and analyzed using SPSS version 26.Descriptive statistics were used as a statistical data analysis method and presented as frequencies and percentages with their corresponding confidence intervals. Logistic regression analysis was used to assess the association between initial tumor size and prolactin level and a P value of 500ng/ml in 56.25% males. 67out of the 69 patients were treated (medical and/or surgical). 59(85.5%)patients had clinical response and 10 (14.5%) had no clinical response.On multivariate logistic regression the prolactin level has strong association with the initial tumor size with p valueen-USProlactinoma, TASH,prolactinoma, medical therapy, dopamine agonistsThesis