Abel ShiferawNatnael Gebeyehu2025-03-202025-03-202024-12-09https://etd.aau.edu.et/handle/123456789/5151Histopathologic examination of colonoscopy biopsies is vital for diagnosing gastrointestinal diseases. Granulomas, focal aggregates of immune cells associated with chronic inflammation, are a key area of study. They can be categorized into foreign body granulomas, which isolate non-reactive substances without a T cell response, and immune granulomas, which involve continuous T cell-mediated reactions. Granulomas exhibit various patterns, such as foreign body, epithelioid, xanthogranulomatous, suppurative, and necrotizing types, each indicating different causes. They can result from infections such as TB, non-infectious conditions like Crohn’s disease, drug reactions, inherited disorders, malignancies, or idiopathic conditions. Accurate classification is crucial for effective management, ranging from antimicrobial therapy to immunosuppressive treatment. Despite challenges in granuloma distribution and morphology, histopathology remains essential for diagnosing intestinal granulomatous disease and differentiating between IBD subtypes and other conditionsen-USColonoscopy BiopsyThesis