Girma, Betelhem (Msc,Lecturer AAU.)Gebeyehu, Geresu2018-11-092023-11-052018-11-092023-11-052018-06http://etd.aau.edu.et/handle/123456789/14086Background: Post anesthesia shivering is one of the potential complications of anesthesia which may increase patient’s morbidity. Nowadays, it has become a common phenomenon with the increasing number of surgeries. Various pharmacological and non-pharmacological methods had been employed to control postoperative shivering. Warming the patient and other alternative methods has been employed over several years, but it was more expensive. Objectives: to compare the effectiveness of intravenous ketamine 0.5mg/kg and pethidine 0.5 mg/kg for post-operative shivering after general anesthesia at black lion specialized hospital from January 1 to April 30, 2018. Methods and materials: an observational cohort study was conducted at black lion specialized hospital from January 1 to April 30, 2018. The study involved 76 ASA I and II patients aged 18- 65 years, undergoing elective surgery under general anesthesia. The patients in the two groups took either ketamine 0.5mg/kg and pethidine 0.5 mg/kg 20 minutes before completion of the surgery. The incidence and severity of post-operative shivering were compared between the two groups every 10 minutes until one hour postoperatively. Categorical data were analyzed with the Chi-Square test and fisher exact test. Parametric data between groups were analyzed using independent samples t-test and non-parametric data were analyzed with Mann-Whitney U test. A p value of <0.05 was considered as a statistically significant. Results: The incidence of shivering between the ketamine and pethidine groups in PACU were (28.2%) and (35.9%) respectively (p=0.467). Grades of shivering were not significantly different between the two groups (p=0.893). Comparison of HR and MAP at different time intervals intraoperatively was found to be comparable between the groups (p>0.05). The scores of axillary temperature at different time intervals during intraoperative and postoperative period have shown comparable values. Conclusion and Recommendation: This study showed that prophylactic low dose IV ketamine reduced postoperative shivering as effectively as pethidine. The study also showed a clinically better outcome in favor of ketamine. We recommend prophylactic low dose IV ketamine 20 minutes before completion of surgery to prevent postoperative shivering.en-USketamine, pethidine, general anesthesia, postoperative shivering, elective surgeryThesis