Fikirtemariam AbebeYordanos Bogale2025-08-122025-08-122024-05-15https://etd.aau.edu.et/handle/123456789/6390Background: Neonates are more likely to show subtle signs of illness. Neonatal danger signs indicate newborns are at high risk of illness and death. Mothers are the first to notice even the smallest changes in newborns; they identify them and treat them at an early age. Mothers must be knowledgeable about neonatal danger signs to guarantee the quality of life for their newborns. Objective: To assess the knowledge on neonatal danger signs and associated factors among early post-natal care mothers in public hospitals of Addis Ababa, Ethiopia, 2024 Methods and Materials: An institutional-based cross-sectional study design was carried out among 360 early post-natal mothers who gave birth in selected public hospitals from February 19 to March 19, 2024. The data were coded, cleaned, and then exported from Kobo Collector application to Statistical Package for Social Science (SPSS) version 27 for analysis. Binary logistic regression was used to identify statistically significant independent variables, and dependent variables with a p-value. Result: Out of 360 mothers 41.4% had good knowledge about neonatal danger sign. Counseling about neonatal danger sign after delivery (AOR: 7.576, 95% CI: 3.174 to 18.086), awareness of neonatal danger signs (AOR: 2.812, 95% CI: 1.035 to 7.644), individuals with primary level education (AOR:3.807, 95% CI: 1.048 to 13.835 ), secondary level education (AOR: 4.741, 95% CI: 1.351to 16.638), college education (AOR: 7.43, 95% CI: 2.087 to 26.455), and ANC follow-up (AOR: 3.699, 95% CI: 1.113 to 12.297), were identified as significant predictors of mothers knowledge about neonatal danger sign . Conclusion: The study reveals that counseling about neonatal danger signs after delivery, maternal awareness of these signs, and maternal education levels are significant predictors of early neonatal danger sign awareness among mothers in Addis Ababa selected public hospitals. Recommendation: Enhancing maternal knowledge on neonatal danger signs is crucial for early intervention and reducing neonatal mortality. Key words: neonate, neonatal danger sign, early postnatal mothers, knowledgeen-USneonate neonatal danger sign early postnatal mothers knowledgeThesis