Sebsibe, Girum(BSc, MSc, PHD fellow)Tesfaye, Tewodros(BSc, MSc)Awgchew, Seifu2020-12-272023-11-062020-12-272023-11-062020-06http://etd.aau.edu.et/handle/123456789/24357Back ground: World Health Organization (WHO) defines birth asphyxia as failure to initiate and sustain breathing during birth. Apgar score is 0-3 for longer than 5 minute lead to developing multisystem organ dysfunction including cardiovascular, neurological, gastrointestinal, pulmonary, and renal system. The aim of this study is to Asses magnitude of prenatal asphyxia and associated factors in admitted neonates at NICU of Worabe Comprehensive Specialized Hospital from January 1/2016 to December 31/2019, Silete zone, South Ethiopia 2020. Facility based retrospective cross-sectional study was conducted from March to April 2020 (by reviewing neonates chart from January1/2016 to December 31/2019). Data was collected through record review using pre-tested structured check lists. Systematic sampling technique was used. The data was entered into statistical software Epidata version 3.1 up on creating the questionnaire template in the QES file of the software Factors associated with perinatal asphyxia among admitted neonates were determined using bivariate and multivariate logistic regression models. Statistically significant associations were declared at P<=0.05. Permission secured at all level. Pre-test was conducted on 5% of sample before the starting of actual data. The collected data checked daily for completeness and no personal identifiers were used on data collection form. The result of this study shows medical records of 311 neonates were reviewed to give prevalence rate of 41.2%.85 (66.4%) of male and43 (33.59%) of female were developed perinatal asphyxia. Preeclampsia during pregnancy (AOR= 6.2, 95%CI :3.1- 12.3), antepartum hemorrhage (AOR= 4.5, 95%CI:2.3- 8.6), gestational diabetes mellitus (AOR= 4.2, 95%CI:1.9-9.2), premature rapture of membrane (AOR= 2.5, 95%CI:1.33-4.7) fetal distress (AOR= 3,95%CI:1.3-7.0) and meconium stained amniotic fluid(AOR= 7.7, 95%CI : 3.1-19.3) were factor significantly associated with perinatal asphyxia. The study conclude that Preeclampsia, antepartum hemorrhage; Gestational diabetes mellitus, premature rapture of membrane; Intra uterine meconium release and fetal distress during labor were associated factors for perinatal asphyxia. The institution should give emphasis on care of mother and the new born in actively detecting and managing perinatal asphyxia.en-USPerinatal asphyxia, magnitude, NICU, associated factor, WCSH.Thesis