Abula, Tefera(Professor, PhD)Sada, Oumer (Assistant Professor)Yassin, Samiya2021-11-262023-11-292021-11-262023-11-292021-07http://etd.aau.edu.et/handle/123456789/28980Stress ulcer is an inflammatory condition involving the gastric mucosa that may appear at some point of physiological stress such as serious illness. Prophylaxis against stress ulcers using Acidsuppressive therapy (AST), such as proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H 2 RAs), often is used to prevent gastric complications, in patients with serious illnesses as they have a high risk of developing gastric ulceration and bleeding. Currently there is a growing concern about improper use of stress ulcer prophylaxis (SUP) in hospitalized patients. Hence, this study was aimed to determine appropriateness and associated factors for the use of SUP among patients treated at adult medical ward and intensive care unit of TASH. An institutional based Cross-Sectional study was conducted from August 9 th , 2019 to December 9 , 2019. Data was collected prospectively from 368 patient medical records. The data were entered into Epi-info version 7 and then exported to and analyzed using Statistical Package for Social Sciences, version 25. Descriptive statistics were used to summarize the data while multivariable binary logistic regression analysis was used to determine factors associated with appropriateness of SUP use. P-value <0.05 was considered as statistically significant. The median age of the study participants was 32 years. Of the included study participants, 144 (39.13%) were on SUP; among patients on SUP more than one-third of them (39.13%) received SUP without an appropriate indicationand140 (62.50 %) patients had indications but did not receive SUP. In multivariable logistic regression, patients who were on NG tube feeding, patients with coagulopathy and history of UGIB, PUD and gastritis showed statically significant association with inappropriateness of SUP use. Inappropriate SUP use was observed in significant number of study participants. Greater proportion of this inappropriateness was attributed to the underutilization of SUP for high-risk patients. Hence, it is necessary to implement and comply to standardized SUP guidelines for ICU and medical ward patients in our hospital setting.en-USTikur Anbessa Specialized Hospital, Stress Ulcer Prophylaxis, Acid Suppressive Therapy, Hospitalized PatientsThesis