Desta, Kassu (Assistant Professor)Ababu, Eden2018-06-282023-11-062018-06-282023-11-062017-06http://etd.aau.edu.et/handle/123456789/4307Background: H.pylori is a gram-negative bacterium found on the luminal surface of the gastric epithelium. At least 50% of the world's human population has H.pylori infection. Studies have shown an increased prevalence of this bacteria in people infected with HIV relied on the CD4 count level. Aim:To determine the burden H.pylori and its association with CD4 count among HIV infected individuals who attend the ART service in Kotebe Health Center, Yeka Sub City, Addis Ababa, Ethiopia. Methods:A cross sectional Study was conducted from October to November 2016 on 388HIV infected individuals at Kotebe Heath Center, Yeka Sub City Addis Ababa. Convenient sampling technique was employed to include study participants who met the inclusion criteria. CD4 count and hemoglobin level with demographic and other variables such as habit of drinking alcohol, habit of eating chat, habit of personal hygienic practice, and also direct stool microscopy examination was included in the study. Results:The prevalence of H.pylori infection among study subject was 54.8%, H.pylori infection among female participant was 51.8% (133/256) and among male participant was 60.6% (87/143) with X2 = 2.745a and P-Value 0.098. The prevalence of H.pylori infection in patient with CD4 count level less than 500 was 54.4% (131/141) and with CD4 count level greater than 500 was 55.1% (81/147).The prevalence of H.pylori was 67.1% (61/91) among HIV clients with people in the house hold greater than four. The prevalence of H.pylori infection among HIV clients those use tanker water, wheel water, pipe water was 50% (2/4), 25% (4/16) and 55.9% (226/401) respectively (X2= 6.114a P. value=0.047). Conclusion: There was no significant association between the prevalence of H.pylori and level of CD4 cell count. But there was significant association between number people in the house hold and type of water used for drinking. And there was no significant association between with socio demographic data like age, sex, marital status, educational level, stage of ART taking, habit for drinking of alcohol, smoking, eating of chat, and habit of hand washing, and pervious history of GIT. The health facility and other responsible body must be conscious in creating awareness on the possible transmission of the disease. Key words: H.pylori stool antigen test, CD4 cells, HIV, ARTenH.pylori stool antigen testCD4 cellsHIVARTThesis