Bane AbateGetachew Yared2025-08-122025-08-122024https://etd.aau.edu.et/handle/123456789/6462Background: Inflammatory Bowel Disease (IBD) represents a group of long-term inflammatory condi ons affec ng the diges ve tract, encompassing both Crohn's disease and ulcera ve coli s. Although these diseases display dis nct pathological and clinical features, they share considerable similari es in their underlying mechanisms, which are not fully understood. Osteoporosis, a prevalent condi on marked by decreased bone density, structural deteriora on of bone ssue, and increased vulnerability to fractures, is frequently diagnosed in individuals with IBD, such as those with Crohn's disease and ulcera ve coli s. It is thought that the heightened risk of osteoporosis and subsequent fractures in IBD pa ents can be a ributed to various factors, including the use of cor costeroids, dietary limita ons, and issues with nutrient absorp on. Objectve: To analyze the risk and associated factors of Osteoporosis in IBD pa ents who are followed at the GI clinic of TASH. Methods: Cross-sec onal study conducted on IBD pa ents followed at the GI clinic in TASH between June 2023 and November 2023. Data was collected from eligible individuals using a structured ques onnaire on sociodemographic characteris cs, GI symptoms, factors associated with Osteoporosis, and IBD-related factors. Data entered into SPSS version 26 and analyzed using descrip ve sta s cs, Pearson correla on, binary logis c and mul variable regression for associa on between variables at a sta s cal significance set at p value <0.05. Results: A total of 117 pa ents with Inflammatory Bowel Disease (CD and UC), were included in the study. There were 81 women and 36 men (F:M= 2.25:1). The mean and SD of the age of the par cipants were 34.8 ± 11.73 years respec vely. The mean and SD value of 10-year Major Osteoporosis fracture risk and 10-year Hip fracture risk in percent were [3.94 ± 3.98] and [0.84 ± 1.01 %] respec vely. From these, 19.6% of the par cipants had an increased osteoporosis and fracture risk. Mul variate logis c regression revealed four factors to be significantly correlated with increased osteoporosis risk in IBD pa ents; UC type IBD (p= 0.024), personal history of osteoporosis (p= 0.001), alcohol consump on history (p=0.005) and glucocor coid use > 1 year. Pearson correla on also revealed increasing age (r= 0.234) (p= 0.011) and prolonged dura on of IBD (r=0.272) (p= 0.003) with increased osteoporosis and fracture risks. 6 | Pa ge Conclusion: The study has revealed increasing age, having UC type of IBD, dura on of IBD, personal history of osteoporosis, alcohol consump on history and glucocor coid use dura on of > 1 year were independent risk factors for increased risk of osteoporosis while increased disease ac vity for both CD and UC had a posi ve correla on to increased osteoporosis risk. Meanwhile sex, BMI, small bowel resec on history and Glucocor coid dose did not have significant associa on with increased risk of osteoporosis. However, further large-scale, prospec ve studies are needed to draw firm conclusions on this subject and develop targeted preven on and treatment strategies for osteoporosis in the IBD popula oen-USThesis