Dr. Tesfaye, Kiflom (MD,Associate Professor of Obstetrics and Gynecology)Dr.Berhanu, Esayas(MD,Associate Professor of Obstetrics and Gynecology)Benti, Melat2022-01-122025-01-082022-01-122025-01-082021-09https://etd.aau.edu.et/handle/123456789/29499Background: Although the risks of adverse pregnancy outcomes associated with anti-D antibodies are reduced after the implementation of immunization to the D antigen, it’s still a concern for most Sub-Saharan African countries, where there is poor and sometimes no Alloimmunization prevention following potentially sensitizing events. This may result in the compromise of the woman’s obstetric care and increase perinatal morbidity and mortality. In Ethiopia the weight of the problem is less known and there is no study done in the study area. This study intended to fill this knowledge gap. Objective: To study prevalence and determinant of Rh Alloimmunization in Rh negative mother in three teaching hospitals (TAH, GMH and ZMH) Addis Ababa, Ethiopia. Methods and Materials: Hospital based cross-sectional study was conducted from 328 Rh negative pregnant women who booked for antenatal and delivery service utilization in TASH, GMH and ZMH from October 2020 to May 2021 to assess prevalence and determinant of Rh Alloimmunization in Rh negative women. The data were collected by means of structured questionnaires. The data were entered, coded and analyzed using Statistical Package for Social Science (SPSS) version 25. Descriptive and logistic regression analyses were conducted. Statistical tests were done at a level of odds ratio with 95% confidence intervals and significance of p < 0.05. Variables with P value < 0.25 during the bivariate analysis were included in the multivariate analysis to see the effect of confounding factors Results and conclusion: The study revealed that prevalence of Rh D negative and Rh Alloimmunization in the study area were 2.1% and 17.1% respectively. Being unemployed, not using prophylaxis’s anti-D, having previous sensitizing event and having two or more pregnancy were statistically significant with Rh alloimmunized (p<0.05). Recommendation: Improvement of access and affordability of anti-D medication. As a nation there is no data that assess the determining factor of Rh Alloimmunization so research must be done with a large sample size to improve the management. In addition assessment of knowledge and practice of the health professional also important.en-USRh alloimmunization , Rh negative womenThesis