Araya, Shambel (MSc)Diriba, Regassa(MSC)Tsegaye, Nebiyu2021-12-122023-11-062021-12-122023-11-062021-09http://etd.aau.edu.et/handle/123456789/29210Background:Helicobacter pylori infections are associated with many complications of pregnancy including preeclampsia and itcolonizes the gastric mucosa of about half of the world‟s population. It has been suggested that Helicobacter pylori infection could contribute to the etiopathogenesis of pre-eclampsia by inducing a pro-inflammatory state. The association H. pylori with preeclampsia needs to be further explored. Objective:To assess magnitude of H. pylori infection and its association with preeclampticpregnant women attending antenatal care at Gandhi Memorial hospital Addis Ababa, Ethiopia, 2021. Methods:Hospital-based case control study was conducted amongclinicallydiagnosed preeclamptic and Non-pre eclamptic pregnant women at Gandhi Memorial Hospital, Addis Ababa, Ethiopia. Stool samples were collected for H. pyloriantigen test from study participants. The collected data was analyzed using statistical methods in SPSSversion23. Simple descriptive statistics was used to present the socio-demographic and clinical characteristics of the study subjects. Association between Clinical variables and H. pyloriinfection was performed with multivariate logistic regression. A p-value of <0.05 at 95% confidence level was considered as statistically significant in all the analyses. Result:A total of 93 cases and 186 controls were included in the study giving that a response rate of 92(98.9%) and 180(96.8%) from all participants that included in the study respectively. In this study, the overall prevalence of H. pyloriinfection in all study participants was 38.9% (106/272). The prevalence of H. pyloriinfection was higher in cases than controls, 54.3% (50/92) vs. 31.1% (56/180) respectively. The mean age was 29.01(SD+4.93) years in cases and 30.37(SD+ 6.2) yeas in control group. Ages 26-35 years accounted for the majority proportion for both cases 62 (67.4%) and controls 128 (71.1%). A positive association was found between H. pylori infection and Preeclampsia (OR: 2.64; 95% CI: 2.41–4.10). Conclusion: H. pylori infection has been found to be associated with preeclampsiawomen. In this study, the prevalence of H. pylori infection was higher in cases than in controls (which was 54.3% vs. 31.1% respectively. “Parity, systolic blood pressure and status of hemoglobin were significantly associated with pre eclamptic women with H-pylori”.Key words:Helicobacter pylori, Pre-eclampsia, Pregnant womenen-USH.pyloriinfection,Pre-eclampsia,Pregnant women,Antenatal careThesis