Araya ShambelDiriba RegassaTsegaye Nebiyu2021-12-122023-11-062021-12-122023-11-062021-09http://etd.aau.edu.et/handle/123456789/29210Background:Helicobacter pylori infections are associated with many complications ofpregnancy including preeclampsia and itcolonizes the gastric mucosa of about half of the world‟spopulation. It has been suggested that Helicobacter pylori infection could contribute to the etiopathogenesisof pre-eclampsia by inducing a pro-inflammatory state. The association H.pylori with preeclampsia needs to be further explored. Objective:To assess magnitude of H. pylori infection and its association with preeclampticpregnantwomen attending antenatal care at Gandhi Memorial hospital Addis Ababa,Ethiopia, 2021. Methods:Hospital-based case control study was conducted among clinically diagnosed preeclamptic and Non-pre eclamptic pregnant women at Gandhi Memorial Hospital, Addis Ababa,Ethiopia. Stool samples were collected for H. pyloriantigen test from study participants. Thecollected data was analyzed using statistical methods in SPSSversion23. Simple descriptivestatistics was used to present the socio-demographic and clinical characteristics of the studysubjects. Association between Clinical variables and H. pyloriinfection was performed withmultivariate logistic regression. A p-value of <0.05 at 95% confidence level was considered asstatistically significant in all the analyses. Result:A total of 93 cases and 186 controls were included in the study giving that a response rateof 92(98.9%) and 180(96.8%) from all participants that included in the study respectively. In thisstudy, the overall prevalence of H. pyloriinfection in all study participants was 38.9% (106/272).The prevalence of H. pyloriinfection was higher in cases than controls, 54.3% (50/92) vs. 31.1%(56/180) respectively. The mean age was 29.01(SD+4.93) years in cases and 30.37(SD+ 6.2)yeas in control group. Ages 26-35 years accounted for the majority proportion for both cases 62(67.4%) and controls 128 (71.1%). A positive association was found between H. pylori infectionand Preeclampsia (OR: 2.64; 95% CI: 2.41–4.10). Conclusion: H. pylori infection has been found to be associated with preeclampsiawomen. Inthis study, the prevalence of H. pylori infection was higher in cases than in controls (which was54.3% vs. 31.1% respectively. “Parity, systolic blood pressure and status of hemoglobin weresignificantly associated with pre eclamptic women with H-pylori”.Key words:Helicobacterpylori, Pre-eclampsia, Pregnant womenen-USH.pyloriinfection,Pre-eclampsia,Pregnant women,Antenatal careThesis