Murugan, Rajalakshmi(Prof)Buzuwork Ketemma(MSc)Gebre Deneke2020-05-292023-11-062020-05-292023-11-062019-06http://etd.aau.edu.et/handle/123456789/21358Background: Nausea and vomiting remain among the most distressing side effects of treatment with chemotherapy. Chemotherapy Induced Emesis Can Impair Quality of Life and poor control of emesis can interrupt or force withdrawal from critical chemotherapy. Therefore, Nurses play crucial roll toward assessment, prevention, and management of Chemotherapy Induced Nausea and Vomiting. Knowledge of Nurses to triage patient problems and assist in the evaluation of symptoms and initiation of interventions,information about the last chemotherapy treatment andevidence from the current emesis guideline, guide the nurse in determining the patient's disposition and treatment. Therefore, it is important to determine and enhance the nurses’ awareness and practice toward chemotherapy induced nausea and vomiting prophylaxis guideline and, reduce barriers that prevents the nurse not to act in line with the guideline. Objectives: To assess awareness, practice and perceived barriers toward current CINV prophylaxis guideline adherence among nurses working at selected hospitals in Addis Ababa,Ethiopia, 2019, Methods: Institution based descriptive study design was used to conduct the study in selected hospitals, at Addis Ababa, from April1-30, 2019. The study area was selected using purposive sampling method. Selection of the study participant by population census method from the source population nurses working in oncology units at selected hospitals. Using population census method 79 nurses were participated with response rate of 97%. The data was cleared and entered in to EPI-data version 4.2 then exported to SPSS version 24. Data analysis result was described in frequencies, means, and standard deviations, the association of demographic variables with nurse’s awareness and practice was done using bivariate and multi- vairate logistic regression. Result: from the total of 79 nurses 49(62%) were female and the mean age of the participant was29.6±4.08years old. only 60% of the study subject have good awareness where as 59% of the participant have poor practice regarding Chemotherapy induced nausea and vomiting guideline adherence. being oncology certified[AOR: 1.477; 95% CI (1.110,1.967)and CINV training[AOR:1.638; 95% CI(1.213, 2.212)]were significantly associated with CINV awareness. Conclusion: nurses working in oncology unit have favorable awareness but they didn’t practice regarding CINV guideline recommendationen-USCINV, Nurses Awareness, Challenges/Barriers, Guideline AdherenceThesis