Miressa BekanaAmsalu Taye2025-08-132025-08-132024-06-07https://etd.aau.edu.et/handle/123456789/6572Less is established about the maternal and fetal effects of chewing khat during gestation and hence, it is problematic to elaborate a robust evidence base on its effects. So far, a few reports exist which demonstrate the relationship between khat chewing and a few birth outcomes. In addition, these limited studies did not perform mediation analysis to explain how khat chewing affected the reported birth outcomes. Therefore, the present study is the first to demonstrate a model that clarifies how selected variables mediate the relationship between khat chewing during gestation and pregnancy outcomes, providing an explanation for how khat chewing during gestation can affect pregnancy outcomes. Additionally, to date there exists no attempt to demonstrate the effects of chewing khat during gestation on maternal, pregnancy and neonatal outcomes in a prospective cohort study design. More importantly, there exists no pervious attempt to demonstrate the effects of chewing khat during gestation on placenta and umbilical cord in histopathologic study approach.en-USChat/khat chewingsubstance use/misuse/abusemagnitudeprevalenceassociated factorsperceived reasonsmaternal outcomesfetal developmentpregnancy outcomesbirth outcomesneonatal outcomesEthiopiaThesis