Daniel BisratTemesgen Kusse2026-06-222026-06-222025-06-10https://etd.aau.edu.et/handle/123456789/8407Infectious diseases place a significant impact on the healthcare system. It causes 7.7 million fatalities each year, with a disproportionately high burden in sub-Saharan Africa. Drug resistant pathogens attributed to 4.95 million are and 1.27 million are brought on by illnesses of bacteria that are resistant to the current medications. Therefore, there is an urgent need for new, safe, and effective compounds to combat antimicrobial resistance (AMR). Inen-US2-Hydroxy-12-diphenylethanoneAntimicrobial activityIn-silico studiesDisulfide bond oxidoreductase (DsbA)Mannich reactionThesis