Kinde, Samuel (MSc, PhD Candidate)Dedefo, Gobena(BSc, MSc)Mengistu, Yordanos2021-01-172023-11-062021-01-172023-11-062020-06http://etd.aau.edu.et/handle/123456789/24710Background: -Khat chewing is a widely heled practice in our society. Moreover, studies about khat chewing effect are contradictory. There is limited data about khat effect on blood glucose specially in our setting. Therefore, this study aims to investigate this issue. Objective: In this study, we compared FBS among khat chewer and khat chewer diabetic and healthy subjects. Method: A cross-sectional study include 200 confirmed diabetic and healthy subjects grouped in to four groups (diabetic khat chewers n=50, diabetic non khat chewer n=50, healthy khat chewer n=50 and healthy non-khat chewer n=50). FBS was determined by enzymatic method (GOD&G HK) using Biosystem A25 and COBAS 6000 chemistry analyzers at Hiwot Fana and St. Peter hospital clinical chemistry laboratory respectively. Non-parametric tests Mann-Whitney test (2independent sample test) and Kruskal-Wals test (K-independents sample test) were used to compare fasting blood glucose among khat chewer and non-khat chewer with in the groups and between groups respectively. P<0.05 is taken to be statistically significant. Result: - Of the total respondents 83(41.5%) and 117(58.5%) were male and female respectively. Without age and gender adjustment the overall Median±IQR FBS difference among khat chewers and non-khat chewers were (159.5±83) mg/dl and (202±79) mg/dl respectively in diabetic patients using GOD. Similarly, when we compare between healthy non-khat chewers and khat chewers, khat chewers have lower (Median±IQR) fasting blood glucose level (82±18) mg/dl than that of the non-khat chewers (94±13) mg/dl when tested by GOD. Generally, there was significantly lower blood glucose level measured by both GOD and GHK methods in both diabetics and healthy groups of khat chewers. There was also percentage difference of median FBS with in the same group when measured by GOD and GHK methods. Conclusion and recommendation: -There was significant effect of khat on blood glucose level among khat chewer and non-khat chewer in diabetic and healthy individuals. Based on the present study finding, further studies have to be conducted to identify khat constituent associated with hypoglycemic effect and further elucidate khat effect on systemic metabolism.en-USKhat chewing, serum fasting glucose levelThesis