Shibeshi, Workineh (PhD, Associate Professor)Alamrew, Kerebih2018-12-302023-11-062018-12-302023-11-062018-12http://etd.aau.edu.et/handle/123456789/15359Assessment of Antibiotics Use as surgical Prophylaxis and Post-Operative Treatment at Saint Paul’s Hospital Millennium Medical College (SPHMMC). Kerebih Alamrew Addis Ababa University, 2018 Surgical site infectionsare the most common types hospital acquired infections. Use of antibiotic, when sound and in the appropriate principle of prophylaxis can result in reduced postoperative infections and mortality. The main objective this work was to assess antibiotics use for prophylaxis and post-operative Treatment of surgical patients in surgical wards of SPHMMC. prospective cross-sectional study was conducted by reviewing records of 413 patients who admitted at the surgery wards of SPHMMC between June 10 and September 10, 2016. Descriptive statistics and binary logistic regression were used for statistical analysis. Of the 413 patients studied,231(55.9%) weremales withmean age of patients 38.1±15.1years (range 13 to 82 years). Most surgical patients 187(54.8%) were given Ceftriaxone as prophylaxis and treatment. Among those who received antimicrobial prophylaxis the time of administration was not recorded in 22 (9%) of the patient.Selection was the most deviated parameter from surgical antibiotic prophylaxis 205(91.5%) followed by duration 99(44.2%), and indication 22(5.3%).Surgical site infection rate was 11.1%. Type of admission (p=0.003) and status surgical antibiotic prophylaxis of use(p=0.045) at p< 0.05 (95% confidence interval) were the risk factors associated with surgical site infection. among patients undergoing surgical procedure at the hospital during the study period. In conclusion the study indicates that ceftriaxone was the most used antibiotics. Use of broader spectrum antibiotics for extended period was common.Areas of non-concordance to the guideline require further investigation.en-USsurgical site infection, Surgery, Antibiotic use, appropriateness, Saint Paul’s Millennium Medical College, Ethiopia.Thesis