Gedefaw TigabuFinot DebebeWondim Aboye2026-06-222026-06-222025https://etd.aau.edu.et/handle/123456789/8261Informed consent is a basic principle for the ethical and legal conduct of healthcare that protects the autonomy of the patient. At present, its practice in the emergency departments (EDs) is hindered by time pressure, lack of patient education, patient ignorance, and emotional distress, notably in low middle income states, such as Ethiopia. Objective: The study aims to is to assess informed consent practice and associated factors influencing its application in emergency departments among residents and nurses of selected governmental hospitals in Addis Ababa Methods: A cross-sectional institutional study was conducted on nurses and residents from three tertiary hospitals, namely Tikur Anbessa Specialized Hospital (TASH), Saint Paul’s Hospital Millenium Medical College (SPHMMC) and Yekatit 12 Medical College. Data were collected on self-administered Google Form, and analyzed using SPSS 27. For multivariate analysis, variables with binary logistic regression (p < 0.25) were used, accounting for potentially confounding factors. Results: Among 157 residents and nurses, 144 were included in this study and 51.8% have good informed consent practice. Residents and nurses with good knowledge about informed consent [AOR: 7.17 (95%CI: 2.267-22.682)], regular supervision from administration [AOR: 4.72 (95%CI: 1.706-13.06)], consideration of patients' cultural norms [AOR: 2.911 (95% CI: 1.024-8.278)] and patients’ incapacity to make decisions [AOR: 0.242 (95% CI: 0.089-0.657)] were significantly associated with informed consent practices. Conclusion: Good informed consent, driven by professional knowledge, administrative oversight, and cultural norms yet challenged by patients’ incapacity to make decisions, can be enhanced through continuous education, robust administrative support, cultural competency training, and clear protocols.enInformed ConsentKnowledgeAttitudeThesis