Habtamu AbebeHailu DanielKedir Zinet2022-01-252023-11-052022-01-252023-11-052021-10http://etd.aau.edu.et/handle/123456789/29640Background: Hepatoblatsoma is the most common primary malignant liver tumor in pediatricsmost often occurs within the first 3 years of age. Most common clinical presentation isabdominal distension or abdominal mass. It is more common in south East Asia and Africa.There are multiple associated factors which determine the magnitude andprognosisactorof hepatoblatsoma. Indeed, Knowledge about the magnitude and outcome of hepatoblatsoma willhelp in designing prevention and early management intervention, thereby reducing the severityof the illness and Death of patients. Methods: A cross-sectionalanalyticalstudywasdonebycollecting retrospective data frompatient charts of patient evaluated at pediatrics hemato-oncology unit at TikurAnbesaa Specialized Hospital (TASH) in Addis Ababa, Ethiopia, during the period June 2010 to July2021GC. All patients whose records meet the inclusion were reviewed. Data cleaning andanalysis was conducted by the principal investigator. The data was summarized using frequencydistributions and summary tables and figures. The data was further analyzed using descriptivestatistics and survival analysis by applying Kaplan Meier statistics. Conclusions of the studywere drawn based on the analyses results. Result: A total of 25 patients fulfill the inclusion criteria were enrolled almost three forth of the study participant were under 2 years, around 52% were females, majority of them were deliveredat term (72%) and had normal birth weight (64%).Most of the patient came from rural area(64%).All patients had abdominal ultrasound and abdominal-pelvic CT scan which is suggestive of HB and around 64% of the mass involve both lobe of the liver. Major clinical manifestations like abdominal mass and abdominal pain were present on allpatients followed by weight loss (80%) and anorexia (64%). Most of the patient had elevatedAFP >1000ng/ml (80%) and thrombocytosis (56%). 64% of the patients had PRETEXT stage 3HB. Magnitude of hepatoblatsoma in the last 10 years in tikuranbesa specialized hospital were(25,2%) when we compared it with total solid tumors seen in the past 10 years . Most of the patient started chemotherapy (21, 84%) ,Cisplatin based regimen was most commonly used regimen. Surgery was done only for 20% of the patient. Almost all post-surgicalpatients got improved. The correlation function of tumor size decrement after treatment with serum AFP after treatment and cycle of chemotherapy had significant correlation with P –value of 0.000 and 0.034respectively. Conclusion: hepatoblatsoma is the most common liver tumor in less than 5 year since surgery isthe main stay of management most of our patients died within 6month to 1 year after hospitalstay even before surgery, almost all of the survived children undergone surgical excision.en-USHepatoblatsoma, serum AFP, abdominal mass, lobe involvement, death.Thesis