Dr. Bulto Giro, Dr Jirata ShiferawWondimu, Hika2020-11-172023-11-302020-11-172023-11-302020-06http://etd.aau.edu.et/handle/123456789/23328The study was conducted from October, 2019 to May, 2020 by using cross-sectional study design to assess a clinic-pathological, lesion characterization, and financial loss due to fasciolosis and hepatic necrobacillosis in cattle slaughtered at three municipal abattoirs of central Ethiopia. Sixty cattle were selected using systematic random sampling for this study, from which blood samples and liver tissue of the same animals were collected before and after slaughter, respectively. Tissue sampling for bacterial culture and histopathology were collected from the infected liver. Post-mortem inspection results, 41.6% (25/60) gross pathologic lesions, of these, 20% (12/60) were mixed infection of liverfluke and Fusobacterium necrophorum while 8% (5/60) and 13.3% (8/60) of the infections were due to Fusobacterium necrophorum and liverflukes alone, respectively. The histopathologic examination of the affected livers indicated heavy infiltration of inflammatory cells, biliary cirrhosis and extensive fibrous of connective tissue proliferation in the hepatic capsule. The hematological assay results indicated that PCV, Hb, and RBC’s were lower in the infected cattle while, the WBC’s (Eosinophilia, Neutrophilia, Monocyte, and Lymphocyte) were higher. The biochemical analysis of blood samples from the infected cattle showed that the liver enzymes AST, ALT, and ALP were significantly higher in animals with hepatocyte degeneration. The estimated financial losses due to liver condemnation by fascioliasis and hepatic necrobascillosis were 1,747,200 ETB/ ($56361.3) annually. Therefore, the study concluded that the liverflukes and infections due to Fusobacterium necrophorum are the major problems of cattle slaughtered at the selected abattoirs of the study areas. Thus, corrective measures and further investigations are recommended to lessen economic loss from fasciollosis caused liver condemnation.enAbattoirCattleFusobacterium necrophorumLiverflukeEthiopia.Thesis